Objective: Combined antiretroviral therapy (cART) in pregnancy traditionally included two nucleoside reverse transcriptase inhibitors plus 1 protease inhibitor (PI). Recently, integrase strand transfer inhibitors (INSTI) have been approved for use in pregnancy. We sought to compare the rate of undetectable VL near delivery in pregnant HIV-infected women receiving INSTI-based versus PI-based cART.
Material And Methods: Prospective cohort study (January 2010-March 2017) of pregnant HIV-infected pregnancies receiving care in a single obstetric infectious disease clinic. Included pregnancies (total = 171; INSTI - group = 111, PI - group = 60) had at least 2 VL (before and after intervention) during pregnancy. The primary outcome was the rate of undetectable VL near delivery.
Results: We found comparable rates of undetectable HIV VL near delivery in pregnancies treated with INSTI-cART (74/111, 66.7%) compared to PI-cART (34/60, 56.7%; [adjusted = .116, RR 1.26, 95% CI 0.92-2.59]). Compared to the PI-group, pregnancies in the INSTI-group showed lower median HIV VL near delivery (20 versus 50 copies/mL; adjusted = .0454) and greater VL reduction (adjusted = .0185). There were 3/171 (1.75%) infants diagnosed with HIV, 1 in the INSTI-group and 2 in the PI-group ( = .5635, RR 0.51, 95% CI 0.10-2.53).
Conclusion: Pregnant HIV-infected women receiving either INSTI- or PI-based cART achieved comparable rates of undetectable HIV VL near delivery with similar perinatal transmission.
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http://dx.doi.org/10.1080/14767058.2019.1691987 | DOI Listing |
J West Afr Coll Surg
October 2024
Adeoyo Maternity Teaching Hospital, Ibadan, Nigeria.
Background: Human immunodeficiency virus (HIV) is a lentivirus. It is transmitted through sexual intercourse, shared intravenous drugs, contaminated needle use, blood transfusion, and mother-to-child transmission. Of the patients with HIV, 50%-75% have ocular manifestations and this may be the primary presentation.
View Article and Find Full Text PDFJ Obstet Gynaecol Res
January 2025
Department of Medical Biochemistry, University of KwaZulu-Natal, Durban, South Africa.
Background: Nutritional risk assessment is an essential component of primary health care screening, especially for pregnant women. The aim of this study was to investigate the relationship between maternal body mass index (BMI) and maternal anthropometric measurements in black South African pregnant women, both with and without human immunodeficiency virus (HIV).
Materials And Methods: A cross-sectional observational study design was used.
BMC Public Health
December 2024
Department of Global Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Mycotoxin Res
November 2024
Immunology Unit, Department of Laboratory Diagnostic and Investigative Sciences, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Aflatoxin B (AFB) and fumonisin B (FB) are poisons that contaminate poorly stored staple foods in resource-limited settings. Antenatal AFB and FB exposure may cause anaemia. We aimed to determine the associations of urinary aflatoxin M (AFM) and FB, biomarkers of AFB and FB exposure, respectively, with erythrocyte parameters and anaemia.
View Article and Find Full Text PDFHeliyon
October 2024
Department of Public Health, Ministry of Health, Addis Ababa, Ethiopia.
Introduction: Depressive disorder is a common mental health issue among perinatal mothers living with HIV, potentially leading to significant despair and anxiety. This condition can hinder maternal-infant bonding and undermine efforts to prevent mother-to-child transmission of HIV. Despite its importance, little is known about the factors associated with depression in this population.
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