AI Article Synopsis
- Cancer is the second leading cause of death globally, but this study explored the link between recurrent pregnancy loss and cancer risk, particularly among Danish women born between 1957 and 1972.
- They used a matched control method, looking at 28,785 cancer cases and 283,294 controls, and found no significant association between pregnancy loss and cancer development across 11 specific cancer types.
- A slight potential link was noted for women with primary recurrent pregnancy loss (three consecutive losses without a live birth), suggesting an odds ratio of 1.27 for overall cancer risk, but this finding may not be significant.
Article Abstract
Background: Cancer is the second leading cause of death worldwide. Few studies have investigated if recurrent pregnancy loss is associated with an increased risk of cancer. We aimed to assess whether pregnancy loss is associated with later cancer development.
Methods: We identified all invasive cancers after age 40, among all Danish women born between January 1957 and December 1972, ensuring a full reproductive history. Cases were matched by birth year 1:10 to cancer-free controls. Women were followed until the end of 2017. The number of pregnancy losses (miscarriages or still births) was correlated to long-term cancer risk using conditional logistic regression, providing odds ratios for specific cancers with different numbers of pregnancy losses, all adjusted for age, education, and other potential confounders.
Findings: The study included 28,785 women with cancer (mean age 48.7 [SD 5.0]) and 283,294 matched controls (mean age 48.6 [SD 5.0]). We found no overall association between pregnancy loss and later development of 11 site-specific types of cancer or cancer overall. Taking the sequence of pregnancy losses into account, primary recurrent pregnancy loss (three consecutive pregnancy losses without prior live birth) was associated with later overall cancer by an odds ratio of 1.27 (1.04-1.56). Secondary recurrent pregnancy loss showed no association to cancer.
Interpretation: Pregnancy loss was not associated with later cancer development. Women with primary recurrent pregnancy loss had a borderline significant association to later cancer overall, this may be a chance finding.
Funding: Ole Kirk's Foundation and Copenhagen University Hospital Rigshospitalet's Research Grant.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833468 | PMC |
| http://dx.doi.org/10.1016/j.eclinm.2019.08.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tubal Sterilization And Vasectomy Increased Among US Young Adults After The Supreme Court Decision In 2022.
Health Aff (Millwood)
January 2025
Julie Maslowsky, University of Michigan, Ann Arbor, Michigan.
Young adults' access to contraception is shifting after the June 2022 United States Supreme Court decision. This concurrent mixed-methods study measured young adults' use of and perceptions about tubal sterilization and vasectomy after the leaked opinion in May 2022. Using national-level medical claims data from IQVIA, we conducted difference-in-differences analyses of tubal sterilizations and vasectomies by age and state policy; using open-text survey responses from national MyVoice surveys in 2022 and 2023, we thematically analyzed young adults' perspectives.
View Article and Find Full Text PDFEyelid Malpositions as Complication of Pregnancy.
Ophthalmic Plast Reconstr Surg
January 2025
Department of Ophthalmology, Madigan Army Medical Center, Tacoma, Washington.
Eyelid malpositions as a complication of pregnancy, in the absence of associated trauma or injury, are rarely encountered. There are limited published reports on this phenomenon or subsequent surgical repair. We present the case of a 38-year-old female who experienced 3 separate episodes of eyelid malpositions, each occurring independently during 3 otherwise uncomplicated pregnancies, which persisted until surgical correction.
View Article and Find Full Text PDFThe landscape of recurrent spontaneous abortion registered on clinical trials.gov.
Front Endocrinol (Lausanne)
December 2024
Department of Good Clinical Practice, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Objective: Recurrent spontaneous abortion (RSA) presents a significant challenge in the field of reproductive medicine, as effective treatments remain limited despite extensive research efforts. A comprehensive understanding of current RSA clinical trials is essential for enhancing trial design and identifying existing research gaps. The aim of this study is to characterize RSA related clinical trials registered on Clinical Trials.
View Article and Find Full Text PDFGenome-wide analysis reveals porcine LIFR regulated by DNA methylation promotes the implantation process via the STAT3 signaling.
Int J Biol Macromol
January 2025
Colleges of Animal Science & Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
Embryo-uterine interaction during embryo implantation depends on the coordinated expression of numerous genes in the receptive endometrium. While DNA methylation is known to play a significant role in controlling gene expression, specific molecular mechanisms underlying this regulatory event remain elusive in early porcine pregnancy. Here, we investigated the genome-wide DNA methylation landscape in the Yorkshire and Meishan pig's endometrium.
View Article and Find Full Text PDFPregnancy With a Stoma is Feasible, Though Associated With Manageable Complications.
Inflamm Bowel Dis
January 2025
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713GZ, Groningen, The Netherlands.
Background: Inflammatory bowel disease (IBD) is often diagnosed in young adults, and therefore frequently coincides with pregnancy. Patients may require surgery that includes (temporary) stoma placement. Literature on the occurrence of stoma-complications during pregnancy and the effect on pregnancy outcomes is limited.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!