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| http://dx.doi.org/10.1016/j.jses.2019.05.003 | DOI Listing |
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A self-forming bone membrane generated by periosteum-derived stem cell spheroids enhances the repair of bone defects.
Acta Biomater
December 2024
Department of Orthopedics, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, PR China; The Third School of Clinical Medicine, Southern Medical University, Guangzhou 510000, PR China. Electronic address:
The periosteum, a highly specialized thin tissue, is instrumental in contributing to as much as 70% of early bone formation. Recognizing the periosteum's vital physiological roles, the fabrication of a biomimetic periosteum has risen as an auspicious strategy for addressing extensive bone defects. In the study, we obtained such biomimetic periosteum by utilizing periosteum-derived stem cells (PDSCs) spheroids.
View Article and Find Full Text PDFWhat Does Pharmaceutical 3D Printing Cost? A Framework and Case Study with Hydrocortisone for Adrenal Insufficiency.
Pharmacoecon Open
December 2024
Erasmus School of Health Policy & Management (ESHPM) & Erasmus Centre for Health Economics Rotterdam (EsCHER), Erasmus University Rotterdam, Burgemeester Oudlaan 50, 3062 PA, Rotterdam, The Netherlands.
Background: Pharmaceutical three-dimensional printing (3DP) technology offers an automated platform that can be utilized to manufacture personalized medicine, improving pharmacotherapy. Although 3D-printed products have entered clinical trials, no costing studies have been performed yet. Cost insights can aid researchers and industry in making informed decisions about the feasibility and scalability of 3DP.
View Article and Find Full Text PDFTemplate-Assisted Electrospinning and 3D Printing of Multilayered Hierarchical Vascular Grafts.
J Biomed Mater Res B Appl Biomater
January 2025
Department of Polymer and Biomaterials Science, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Szczecin, Poland.
Fabricating complex hierarchical structures mimicking natural vessels and arteries is pivotal for addressing problems of cardiovascular diseases. Various fabrication strategies have been explored to achieve this goal, each contributing unique advantages and challenges to the development of functional vascular grafts. In this study, a three-layered tubular structure resembling vascular grafts was fabricated using biocompatible and biodegradable copolymers of poly(butylene succinate) (PBS) using advanced manufacturing techniques.
View Article and Find Full Text PDFMotion analysis for objective evaluation of psychomotor skills in Endoscopic Sinus Surgery.
Rhinology
December 2024
Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan.
Background: This study aims to digitalize surgical maneuvers in ESS using a motion capture system under standardized conditions provided by 3D printed-sinus models.
Methodology: Forty-seven otolaryngologists performed ESS on 3D printed models manufactured from computed tomography (CT) images of actual patients. Participants were classified to 3 groups according to the objective structured technical skills assessment score.
The preparation of 3D-printed self-healing hydrogels composed of carboxymethyl chitosan and oxidized dextran via stereolithography for biomedical applications.
Int J Biol Macromol
December 2024
National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathum Thani 12120, Thailand.
This study presents a new approach for fabricating 3D-printed self-healing hydrogels via light-assisted 3D printing, utilizing Schiff-base and covalent bonding formations resulting from the reaction between amine and aldehyde functional groups alongside the photopolymerization of methacrylate groups. Two distinct polymers, carboxymethyl chitosan (CMCs) and dextran, were first modified to yield methacrylate-modified carboxymethyl chitosan (CMCs-MA) and oxidized dextran (OD). The structural modifications of these polymers were confirmed using spectroscopic techniques, including H NMR and FTIR analyses.
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