Young adults in the U.S. report high levels of stress which are known to contribute to depression and anxiety. Regular cannabis users frequently cite coping with stress as their primary motivation for use. However, research indicates that coping motives are associated with potentially negative outcomes, including cannabis-related problems and negative affect. Therefore, the theoretical rationale for the present study is that using cannabis to cope with stress may be maladaptive as it may exacerbate the same problems users are trying to ameliorate. That is, using cannabis to cope may potentiate links between stress and negative affect. We therefore sought to investigate whether cannabis use motives moderate the associations between stress and negative affect. A sample of 988 cannabis using college students completed an anonymous online survey containing measures of cannabis use, cannabis use motives, stress, depression, and anxiety. Correlation analyses revealed significant positive relationships between these variables. Moderation analyses indicated that coping motives was a significant moderator of the relationship between stress and depression, controlling for anxiety. In contrast, expansion and conformity motives were significant moderators of the relationship between stress and anxiety, controlling for depression. While cannabis may provide temporary relief from symptoms of stress, depression, and anxiety, using cannabis to cope may be related to higher levels of depression, and use of cannabis for expansion and conformity may be related to higher levels of anxiety. These findings have practical implications and contribute to emerging evidence demonstrating that motives for cannabis use may predict differential mental health outcomes.
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http://dx.doi.org/10.1016/j.addbeh.2019.106188 | DOI Listing |
Nucleosides Nucleotides Nucleic Acids
January 2025
Division of Hematology, Department of Internal Medicine, Medical Faculty, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
Breast cancer is the most common malignancy that affects women. MicroRNAs (miRNAs) play an essential role in cancer therapy and regulate many biological processes such as cisplatin resistance. The study's objective was to determine whether miR-182 dysregulation was the cause of cisplatin resistance in TNBC cell line MDA-MB-231.
View Article and Find Full Text PDFIntroduction: Transgender individuals may face familial and social hostility, leading to distress that significantly affects their well-being. This study aims to understand life course challenges experienced by transgender people since childhood.
Method: Cross-sectional study, including 20 transgender people.
J Wound Care
January 2025
Nursing and Health Care, School of Health Sciences, South East Technological University, Waterford City, Ireland.
Objective: Wound management can be costly and challenging to the health services' scarce resources. Information regarding the number of wounds in a community care setting and their associated aetiology will provide nurses and nurse managers with an insight into the specific needs of these clients with wounds and highlight areas where care or services can be improved or further developed. This research aimed to establish the prevalence and aetiology of wounds, the current delivery of wound care, wound documentation and referral pathways in an Irish community care setting.
View Article and Find Full Text PDFJ Foot Ankle Res
March 2025
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Background: Midfoot pain is common but poorly understood, with radiographs often indicating no anomalies. This study aimed to describe bone, joint and soft tissue changes and to explore associations between MRI-detected abnormalities and clinical symptoms (pain and disability) in a group of adults with midfoot pain, but who were radiographically negative for osteoarthritis.
Methods: Community-based participants with midfoot pain underwent an MRI scan of one foot and scored semi-quantitatively using the Foot OsteoArthritis MRI Score (FOAMRIS).
J Cachexia Sarcopenia Muscle
February 2025
Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany.
Background: Despite a phenylalanine (Phe) restrictive diet, most adult patients with 'classical' phenylketonuria (PKU) maintain life-long Phe concentrations above the normal range and receive tyrosine (Tyr) and protein-enriched diets to maintain acceptable concentrations and ensure normal development. While these interventions are highly successful in preventing adverse neuropsychiatric complications, their long- term consequences are incompletely explored. We observed early cardiomyopathic characteristics and associated hemodynamic changes in adult PKU patients and present here the results of a longitudinal evaluation of cardiac phenotype.
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