AI Article Synopsis
- Recent studies suggest that the galanin peptide family can influence glucose metabolism and may help reduce insulin resistance, potentially lowering the risk of developing type 2 diabetes.
- Discovered in 1983, galanin is a gut-derived peptide hormone that plays various roles, including regulating gut motility and body weight.
- This review explores the metabolic effects of the galanin peptide family, focusing on its ability to regulate glucose levels and discussing its potential as a treatment for glucose intolerance and type 2 diabetes.
Article Abstract
Recent preclinical and clinical studies have indicated that the galanin peptide family may regulate glucose metabolism and alleviate insulin resistance, which diminishes the probability of type 2 diabetes mellitus. The galanin was discovered in 1983 as a gut-derived peptide hormone. Subsequently, galanin peptide family was found to exert a series of metabolic effects, including the regulation of gut motility, body weight and glucose metabolism. The galanin peptide family in modulating glucose metabolism received recently increasing recognition because pharmacological activiation of galanin signaling might be of therapeutic value to improve insuin resistance and type 2 diabetes mellitus. To date, however, few papers have summarized the role of the galanin peptide family in modulating glucose metabolism and insulin resistance. In this review we summarize the metabolic effect of galanin peptide family and highlight its glucoregulatory action and discuss the pharmacological value of galanin pathway activiation for the treatment of glucose intolerance and type 2 diabetes mellitus.
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| http://dx.doi.org/10.1016/j.yfrne.2019.100801 | DOI Listing |
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