AI Article Synopsis

  • Continuous flow-left ventricular assist devices (CF-LVADs) are used to treat advanced heart failure, but they increase the risk of gastrointestinal bleeding (GIB), particularly noted in Japanese patients.
  • In a study of 54 patients who received CF-LVADs, 14% experienced GIB, with older age and larger pre-operative inferior vena cava diameter linked to higher risk, and the Jarvik 2000 device identified as a significant risk factor.
  • Most GIB cases occurred in the small intestine due to angiodysplasia, and while 85.8% of patients remained GIB-free after one year, further research is encouraged to better understand the GIB incidence in Japanese populations via multicenter studies.

Article Abstract

Continuous flow-left ventricular assist devices (CF-LVADs) have become a therapeutic option in the management of advanced heart failure. Several studies show that patients with CF-LVAD are at an increased risk of gastrointestinal bleeding (GIB). However, few reports have presented the characteristics of GIB in Japanese populations. We investigated the incidence, etiology, and outcome of GIB in patients with CF-LVAD. Records of adult patients who received CF-LVADs between October 2008 and January 2017 were reviewed. GIB was defined as detection of bleeding sites by any type of diagnostic imaging. 54 patients received CF-LVAD, of which eight (14%) presented with overt GIB (12 events). GIB patients are significantly older (p = 0.04) and their pre-operative inferior vena cava diameter was larger (p = 0.02). Multivariate analysis revealed that the use of Jarvik 2000 (p = 0.003) was a risk factor for GIB. In total, 85.8% of patients were free from GIB at 1 year. The most common site was the small intestine (67%). The most common cause was angiodysplasia (50%). Six patients required blood transfusion (nine events) and four underwent endoscopic clippings (five events); however, no patients needed surgeries. The incidence of GIB in our cohort was similar to the global registry data. Double balloon endoscopy is useful for diagnosis and treatment of small intestinal lesions. Future efforts to further understand the incidence of GIB in Japanese populations by multicenter data are needed.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10047-019-01138-yDOI Listing

Publication Analysis

Top Keywords

gib
10
patients
9
gastrointestinal bleeding
8
ventricular assist
8
patients cf-lvad
8
gib japanese
8
japanese populations
8
gib patients
8
patients received
8
incidence gib
8

Similar Publications

Impact of diagnostic coding schemas on major bleeding risk assessment for oral anticoagulants in patients with atrial fibrillation using administrative claims data.

J Thromb Haemost

December 2024

Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, No. 33, Linsen S. Rd., Zhongzheng Dist., Taipei City 100, Taiwan; Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan, No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei City 100, Taiwan; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, No. 33, Linsen S. Rd., Zhongzheng Dist., Taipei City 100, Taiwan. Electronic address:

Introduction: This study evaluated how different published diagnostic coding schemas impact the assessment of major bleeding risks associated with direct oral anticoagulants (DOACs) and warfarin.

Methods: This retrospective cohort study included patients with atrial fibrillation who initiated DOACs or warfarin between 2012 and 2019, using Taiwan's national claims database. Major bleeding events, including gastrointestinal bleeding (GIB), intracranial hemorrhage (ICH), and other major bleeding events, were identified using coding schemas from Cunningham et al, the Mini-Sentinel protocol, and Yao et al.

View Article and Find Full Text PDF

Background: The adverse effects of aspirin are dose-dependent, and there is controversy surrounding the use of low-dose (LD) aspirin to prevent venous thromboembolism (VTE) following total joint arthroplasty (TJA). This meta-analysis sought to compare the efficacy and complication rate of low-dose (162 mg per day) versus high-dose (HD, 650 mg per day) aspirin after TJA surgery.

Methods: In four main databases, we searched from inception until September 2024 for articles comparing the rate of VTE following TJA(TKA/THA) using only aspirin chemoprophylaxis with different dosages.

View Article and Find Full Text PDF

Background And Aim: The risk of gastrointestinal bleeding (GIB) remains a concern with the use of direct oral anticoagulants (DOAC). We evaluated the efficacy of four risk-scoring models (HAS-BLED, ATRIA, VTE-BLEED, and ORBIT) in predicting GIB according to the concomitant use of antiplatelet therapy in DOAC users.

Methods: Patients prescribed DOAC between December 2014 and October 2020 were enrolled in two university-affiliated hospitals.

View Article and Find Full Text PDF

Vγ9Vδ2 T cells constitute a homogeneous effector T cell population that lyses tumors of different origin, including the prostate. We generated a bispecific T cell engager (bsTCE) to direct Vγ9Vδ2 T cells to PSMA prostate cancer (PCa) cells. The PSMA-Vδ2 bsTCE triggered healthy donor and PCa patient-derived Vγ9Vδ2 T cells to lyse PSMA PCa cell lines and patient-derived tumor cells while sparing normal prostate cells and enhanced Vγ9Vδ2 T cell antigen cross-presentation to CD8 T cells.

View Article and Find Full Text PDF

Exploring multivalency-driven sensitivity modulation for optimization and fine-tuning of avidity-based biosensors.

Biosens Bioelectron

November 2024

Department of Biochemistry, Kangwon National University, Chuncheon, 24341, South Korea; Institute of Life Sciences (ILS), Kangwon National University, Chuncheon, 24341, South Korea; Global/Gangwon Innovative Biologics-Regional Leading Research Center (GIB-RLRC), Kangwon National University, Chuncheon, 24341, South Korea. Electronic address:

The development of multivalent nanoprobes has garnered considerable interest due to their enhanced sensitivity and precision in diagnosing and monitoring diverse diseases. Despite significant advances in nanobiotechnology, the optimal density of binding motifs to maximize the diagnostic efficacy of biosensors remains incompletely understood. Herein, we investigate the influence of multivalency in the functional performance of avidity-based biosensors.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!