The subjective experience of anxiety frequently signals a person's unfulfilled attempts to manage recent environmental or internal challenges. The consequences of stress-related anxiety can be found in most of the body systems: cardiovascular disorders, gastrointestinal ailments, problems with the reproductive system, dermatologic disorders, and autoimmune disturbances--all have been shown to be greatly influenced by anxiety. In addition, studies of hostages and prisoners of war indicate that a person's reactions to extreme stress are predictive of his or her future physical and mental health. Thus, extreme stress-related anxiety must be identified and treated early to protect the patient from a lifetime of chronic illness.
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Stress
December 2025
Department of Preclinical Fluid Biomarkers & Occupancy, H. Lundbeck A/S, Valby, Denmark.
Chronic stress and stress-related mental illnesses such as major depressive disorder (MDD) constitute some of the leading causes of disability worldwide with a higher prevalence in women compared to men. However, preclinical research into stress and MDD is heavily biased toward using male animals only. Aberrant activity of the hypothalamic-pituitary-adrenal (HPA) axis has been linked to the development of MDD and several animal models of MDD have been established based on HPA axis dysregulation.
View Article and Find Full Text PDFJ Neurosci Res
January 2025
Department of Psychology, University of Regensburg, Regensburg, Germany.
Anxiety and depression disorders show high prevalence rates, and stress is a significant risk factor for both. However, studies investigating the interplay between anxiety, depression, and stress regulation in the brain are scarce. The present manuscript included 124 law students from the LawSTRESS project.
View Article and Find Full Text PDFThe COVID Stress Scales (CSS; Taylor et al., 2020b) were developed as a measure of stress related to any pandemic, making it a valuable self-report measure for potential future large-scale infectious disease outbreaks. Although the initial validation study of the CSS indicated evidence of its psychometric strength, further assessment is warranted of the measure's retest reliability, the long-term stability of its five-factor structure, discriminant validity, and its relationship with pandemic-related risk and precautionary behaviors.
View Article and Find Full Text PDFFish Physiol Biochem
January 2025
Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
Stress plays a key role in mental, neurological, endocrine, and immune disorders. The zebrafish (Danio rerio) is rapidly gaining popularity as s model organism in stress physiology and neuroscience research. Although the leopard (leo) fish are a common outbred zebrafish strain, their behavioral phenotypes and stress responses remain poorly characterized.
View Article and Find Full Text PDFBMJ Open
January 2025
Department of Anesthesiology, People's Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China
Introduction: Patients undergoing surgical procedures are often prone to developing acute stress disorder (ASD) postoperatively. Presently, oxytocin nasal spray has shown significant potential in the treatment of stress-related neuropsychiatric diseases. However, there are few reports on the use of oxytocin nasal spray in postoperative ASD, a condition that can potentially develop into a high-risk factor for post-traumatic stress disorder.
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