Two patients with depression that was refractory to tricyclic antidepressant therapy alone and in combination with lithium or triiodothyronine (T3) were treated with the monoamine oxidase inhibitor phenelzine. In both cases, the addition of T3 potentiated the antidepressant response to phenelzine. These observations suggest that thyroid hormone potentiation may not be specific to one class of antidepressant drugs.
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