Clinical correlates of ECT-resistant depression in the elderly.

J Clin Psychiatry

Department of Psychiatry, University of Western Ontario, London, Canada.

Published: October 1988

AI Article Synopsis

  • A study compared 11 patients who didn't respond to antidepressants and ECT with 19 patients who did respond, both groups having similar backgrounds.
  • The findings indicated that nonresponders had physical illnesses during their index episode and fewer stressful life events before their depression began.
  • Additionally, nonresponders had a history of more frequent and longer-lasting depressive episodes compared to those who responded well to treatment.

Article Abstract

Clinical findings in a group of 11 patients who failed to respond to at least one course of antidepressant (usually tricylic) treatment and at least seven bilateral electroconvulsive treatments (ECTs) were compared with the findings in a group of 19 patients with similar sociodemographic characteristics who were responsive to ECT. The major correlates of ECT nonresponse were onset of physical illness during the index episode, fewer life events preceding the onset of the index episode, and a higher frequency of preceding depressive episodes of longer duration in the nonresponder group.

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