The CYFIP1 gene has been linked to autism and schizophrenia and, while there is a noted heterogeneity, both have been characterized to be disorders of connectivity. Recent studies by Dominquez-Iturza et al. and Silva et al. provide direct evidence for CYFIP1 in functional and structural connectivity in the brain.
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http://dx.doi.org/10.1016/j.tins.2019.10.005 | DOI Listing |
Brain Commun
January 2025
Department of Neurology, Inselspital, University Hospital Bern, University of Bern, 3010 Bern, Switzerland.
Personalized prediction of stroke outcome using lesion imaging markers is still too imprecise to make a breakthrough in clinical practice. We performed a combined prediction and brain mapping study on topographic and connectomic lesion imaging data to evaluate (i) the relationship between lesion-deficit associations and their predictive value and (ii) the influence of time since stroke. In patients with first-ever ischaemic stroke, we first applied high-dimensional machine learning models on lesion topographies or structural disconnection data to model stroke severity (National Institutes of Health Stroke Scale 24 h/3 months) and functional outcome (modified Rankin Scale 3 months) in cross-validation.
View Article and Find Full Text PDFNeurology
February 2025
Department of Advanced Biomedical Sciences, University "Federico II," Naples, Italy.
Background And Objectives: Although multiple sclerosis (MS) can be conceptualized as a network disorder, brain network analyses typically require advanced MRI sequences not commonly acquired in clinical practice. Using conventional MRI, we assessed cross-sectional and longitudinal structural disconnection and morphometric similarity networks in people with MS (pwMS), along with their relationship with clinical disability.
Methods: In this longitudinal monocentric study, 3T structural MRI of pwMS and healthy controls (HC) was retrospectively analyzed.
Cureus
December 2024
Neurology, Sheikh Shakhbout Medical City (SSMC) and Mayo Clinic, Abu Dhabi, ARE.
The corpus callosum is a large subcortical white matter region in the brain that contains fiber connecting both cerebral hemispheres together; it has a rich blood supply; hence, infarction in this region is rare. There are a few reported cases of corpus callosal infarction, and here we present our patient who had a clinical presentation that was not suggestive of corpus callosal infarction. However, an MRI brain confirmed the location, and the patient was managed following the standard stroke treatment, and vascular risk factors were addressed and managed.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Thermosensory signals may contribute to the sense of body ownership, but their role remains highly debated. We test this assumption within the framework of pathological body ownership, hypothesising that skin temperature and thermoception differ between right-hemisphere stroke patients with and without Disturbed Sensation of Ownership (DSO) for the contralesional plegic upper limb. Patients with DSO exhibit lower basal hand temperatures bilaterally and impaired perception of cold and warm stimuli.
View Article and Find Full Text PDFCortex
December 2024
Cognitive Neuroscience, Institute of Neuroscience & Medicine (INM-3), Forschungszentrum Jülich, Jülich, Germany; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
The precise cognitive mechanisms underlying spatial neglect are not fully understood. Recent studies have provided the first evidence for aberrant behavioral and electrophysiological prediction and prediction error responses in patients with neglect, but also in right-hemispheric (RH) stroke patients without neglect. For prediction-dependent attention, as assessed with Posner-type cueing paradigms with volatile cue-target contingencies, studies in healthy volunteers point to a crucial role of the right temporo-parietal junction (rTPJ) - as part of a network commonly disrupted in neglect.
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