AI Article Synopsis

  • Russia started using a vaccine called PCV13 in 2014 to protect children from pneumonia!
  • A study looked at healthy kids under 6 in different cities from 2016 to 2018, finding that most had not finished the full vaccine series!
  • The results showed that vaccinated kids had fewer of the vaccine-targeted germs but more of other types compared to unvaccinated kids!

Article Abstract

Russia introduced PCV13 in 2014. We studied the serotype composition of S. pneumoniae isolated from the nasopharynx of healthy children younger than 6 years in St. Petersburg, Smolensk, Perm, Krasnoyarsk, Khanty-Mansiysk and Khabarovsk, between 2016 and 2018. 2.4% of children had completed a 3-dose course of PCV13, while 25.6% had received 1 or 2 doses. Pneumococcal DNA detection by PCR demonstrated S. pneumoniae in 37.2% of samples with regional variation between sites (27.3 to 56.9%). There was little difference between vaccinated, partially vaccinated and un-vaccinated children. Children who had received at least 1 dose of PCV13 had lower carriage rates of vaccine serotypes than their unvaccinated peers (49.9 vs. 61.4%; p < 0.001). Children who had received at least 1 dose of PCV13 showed increased carriage rates of non-vaccine serotypes (50 vs 38.6%; P < 0.001). Especially serogroup 15AF was more prevalent among fully immunized children than among their peers (12.5 vs 2.7%; P < 0.05).

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Source
http://dx.doi.org/10.1016/j.diagmicrobio.2019.114914DOI Listing

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