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Steroidal constituents from Helleborus thibetanus and their cytotoxicities. | LitMetric

Steroidal constituents from Helleborus thibetanus and their cytotoxicities.

Chin J Nat Med

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an 710069, China. Electronic address:

Published: October 2019

AI Article Synopsis

  • Four new steroidal compounds, Thibetanosides E-H, were discovered in Helleborus thibetanus, including three rare sulfonates.
  • A total of nine known steroidal compounds were also identified, and their structures were confirmed using advanced spectroscopic methods.
  • The cytotoxic activities of the compounds were tested against several tumor cell lines, revealing that specific compounds like thibetanoside C and another complex compound showed significant cancer-fighting potential.

Article Abstract

Thibetanosides E-H (1-4), four new steroidal constituents including three rare sulfonates (2-4), were isolated from the roots and rhizomes of Helleborus thibetanus, together with nine known steroidal compounds (5-13). Their structures were elucidated by detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical evidence. In this study, compounds 2-13 were evaluated for their cytotoxic activities against HCT116, A549 and HepG2 tumor cell lines in vitro. Among them, compound 8 (thibetanoside C) showed cytotoxicities against A549 cells(IC 39.6 ± 1.9 μmol·L) and HepG2 cells(IC 41.5 ± 1.1 μmol·L), respectively. Compound 9 (23S, 24S)-24-[(O-β-D-fucopyranosyl)oxy]-3β, 23-dihydroxy-spirosta-5, 25(27)-diene-1β-ylO-(4-O-acetyl- α-L-rhamnopyranosyl)-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-α-L-arabinopyranoside) showed cytotoxicity against HCT116 cells(IC 33.6 ± 2.1 μmol·L).

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Source
http://dx.doi.org/10.1016/S1875-5364(19)30094-9DOI Listing

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