[Clinical and genetic analysis of a patient with Hb Ottawa in conjunction with β -thalassemia].

Objective: To analyze the hematological characteristics of a patient with Hb Ottawa in conjunction with β -thalassemia.

Methods: Peripheral blood samples from the proband and her parents were collected and subjected to red blood cell analysis and hemoglobin electrophoresis. Genotypes of α - and β -globin genes were also analyzed.

Results: The proband and her mother were both heterozygotes for Hb Ottawa and β -thalassemia variant IVS II-654, and presented with typical β -thalassemia trait featuring hypochromic microcytic anemia. An abnormal hemoglobin band was detected upon electrophoresis.

Conclusion: Co-existence of Hb Ottawa and β -thalassemia may not aggravate the phenotype.