AI Article Synopsis
- Using chemically modified extracellular matrix proteins and light can help bond tissues while reducing inflammation and scarring.
- Full-length collagen proteins are hard to produce, so using shorter collagen-like peptides that mimic collagen could be a better option for creating adhesive materials.
- In tests on mice, these photoactivated adhesives reduced scar formation and encouraged skin healing.
Article Abstract
Using chemically modified extracellular matrix proteins, such as collagen, in combination with light for tissue bonding reduces inflammation and minimizes scarring. However, full length animal or recombinant human collagen proteins are difficult to isolate/produce. Thus, short biomimetic collagen peptides with properties equivalent to collagen at both structural and functional levels may be ideal building blocks for the development of remotely triggered adhesives and fillers. In this work, the conjugation of self-assembling collagen-like peptides to acrylate functionalized polyethylene glycol units yielded adhesive filler materials activated by visible light through the incorporation of a photosensitizer. When tested in a murine skin wound model, the photoactivated adhesives showed reduced scar formation and promoted epithelial regeneration.
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| http://dx.doi.org/10.1021/acsami.9b18891 | DOI Listing |
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