Herein, we report the generation of simple condensates of short peptides with ATP, which are spatiotemporally formed under dissipative conditions created in presence of ATP-ase. These coacervates could imbibe cytochrome c and temporally modulate a redox reaction catalyzed by the entrapped protein, thus mimicking the advanced functional machinery of transient intercellular membraneless condensates of large proteins and RNA.
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http://dx.doi.org/10.1039/c9cc07358b | DOI Listing |
J Am Chem Soc
January 2025
Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
Biomolecular condensation lays the foundation of forming biologically important membraneless organelles, but abnormal condensation processes are often associated with human diseases. Ribonucleic acid (RNA) plays a critical role in the formation of biomolecular condensates by mediating the phase transition through its interactions with proteins and other RNAs. However, the physicochemical principles governing RNA phase transitions, especially for short RNAs, remain inadequately understood.
View Article and Find Full Text PDFAcc Chem Res
January 2025
Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ConspectusReactions of gas phase molecules with surfaces play key roles in atmospheric and environmental chemistry. Reactive uptake coefficients (γ), the fraction of gas-surface collisions that yield a reaction, are used to quantify the kinetics in these heterogeneous and multiphase systems. Unlike rate coefficients for homogeneous gas- or liquid-phase reactions, uptake coefficients are system- and observation-dependent quantities that depend upon a multitude of underlying elementary steps.
View Article and Find Full Text PDFWater Res
January 2025
Department of Global Smart City, Sungkyunkwan University (SKKU), 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea. Electronic address:
Food waste condensate (FWC) is a valuable source for recovering short-chain fatty acids (SCFAs) through methods such as supported liquid membrane contactors. Containing organic compounds like acetate, propionate, and butyrate, FWC offers a rich substrate for efficient SCFA extraction. Recovering SCFAs from FWC provides notable environmental advantages, including reducing waste and generating high-value products for industries such as bioenergy and chemical production.
View Article and Find Full Text PDFChem Biodivers
January 2025
Taibah University, Chemistry, Um alqara, Alula, SAUDI ARABIA.
In the current study, new pyranopyrazole analogues (9a-d and 10a-d) were synthesized through a one-pot condensation reaction of 2-arylacetohydrazide. The inhibitory abilities were investigated against the XO enzyme through experimental and molecular docking analyses. The synthesis studies were based on ultrasound-mediated condensation reactions of four-component systems containing 2-arylacetohydrazide, ethyl acetoacetate, indoline-2,3-dione, and ethyl 2-cyanoacetate/malononitrile in various solvents and catalysts to yield pyranopyrazole analogues (9a-d and 10a-d) in a short reaction time and remarkably favorable yields ranging from 79-92%.
View Article and Find Full Text PDFJ Conserv Dent Endod
November 2024
Department of Conservative Dentistry and Endodontics, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India.
Background: Long-term durability of a restoration relies on the marginal integrity and its ability to withstand the occlusal forces. Fiber-reinforced composites (FRCs) exhibited superior properties in terms of fracture toughness, flexural strength, and wear resistance.
Aim: The aim of this study was to assess and compare marginal adaptation and microtensile bond strength (µTBS) of posterior FRCs comparing with a condensable composite.
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