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F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode. | LitMetric
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F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode.

Robert K Leśniak Anna M Rydzik Jos J A G Kamps Amjad Kahn Timothy D W Claridge Christopher J Schofield

Chem Commun (Camb)

The Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

Published: December 2019

The final step in the biosynthesis of l-carnitine in humans is catalysed by the 2-oxoglutarate and ferrous iron dependent oxygenase, γ-butyrobetaine hydroxylase (BBOX). 1H and 19F NMR studies inform on the BBOX mechanism including by providing evidence for cooperativity between monomers in substrate/some inhibitor binding. The value of the 19F NMR methods is demonstrated by their use in the design of new BBOX inhibitors.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927413PMC
http://dx.doi.org/10.1039/c9cc06466dDOI Listing

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