The final step in the biosynthesis of l-carnitine in humans is catalysed by the 2-oxoglutarate and ferrous iron dependent oxygenase, γ-butyrobetaine hydroxylase (BBOX). 1H and 19F NMR studies inform on the BBOX mechanism including by providing evidence for cooperativity between monomers in substrate/some inhibitor binding. The value of the 19F NMR methods is demonstrated by their use in the design of new BBOX inhibitors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927413 | PMC |
| http://dx.doi.org/10.1039/c9cc06466d | DOI Listing |
Publication Analysis
Top Keywords
nmr studies
8
γ-butyrobetaine hydroxylase
8
19f nmr
8
studies γ-butyrobetaine
4
hydroxylase provide
4
provide mechanistic
4
mechanistic insights
4
insights dual
4
dual inhibition
4
inhibition mode
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!