We present local direct imaging of the progressive adsorption of colloidal particles inside a 3D model porous medium. By varying the interparticle electrostatic interactions, we observe a large range of particle deposition regimes, from a single layer of particles at the surface of the medium to multiple layers and eventually clogging of the system. We derive the complete deposition dynamics and show that colloid accumulation is a self-limited mechanism towards a deposited fraction associated with a balance between the particle interactions and the imposed flow rate. These trends are explained and predicted using a simple probability model considering the particle adsorption energy and the variation of the drag energy with evolving porosity. This constitutes a direct validation of speculated particle transport mechanisms, and a further understanding of accumulation mechanisms.
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http://dx.doi.org/10.1103/PhysRevLett.123.158005 | DOI Listing |
Endocrinol Diabetes Metab Case Rep
July 2024
University of California, San Diego, California, USA.
Summary: A 6.6-year-old female presented to endocrinology with precocious puberty for evaluation and management. Workup was initiated, and a diagnosis of central precocious puberty was confirmed.
View Article and Find Full Text PDFNano Lett
August 2024
Department of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
Mild photothermal therapy (PTT) shows the potential for chemosensitization by tumor-localized P-glycoprotein (P-gp) modulation. However, conventional mild PTT struggles with real-time uniform temperature control, obscuring the temperature-performance relationship and resulting in thermal damage. Besides, the time-performance relationship and the underlying mechanism of mild PTT-mediated P-gp reversal remains elusive.
View Article and Find Full Text PDFBiochem Biophys Res Commun
September 2024
Matthew Mailing Centre for Translational Transplantation Studies. Lawson Health Research Institute, London, Canada; Department of Pathology, Western University, London, Canada; Multi-Organ Transplant Program, London Health Sciences Centre. London, Canada; Division of Nephrology, Department of Medicine, Western University. London, Canada. Electronic address:
Cardiac ischemia results in anaerobic metabolism and lactic acid accumulation and with time, intracellular and extracellular acidosis. Ischemia and subsequent reperfusion injury (IRI) lead to various forms of programmed cell death. Necroptosis is a major form of programmed necrosis that worsens cardiac function directly and also promotes inflammation by the release of cellular contents.
View Article and Find Full Text PDFPharmaceuticals (Basel)
March 2024
Allergy Unit, 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University General Hospital 'Attikon', 12462 Athens, Greece.
Angiotensin-converting enzyme (ACE) inhibitors are used primarily in the treatment of hypertension, heart failure, and in the acute phase of myocardial infarction. Lisinopril [N-[(1S)-1-car-boxy-3-phenylpropyl]-L-lysyl-L-proline], enalapril [(S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline] and ramipril [2-aza-bicyclo-[3.3.
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