AI Article Synopsis
- Tissue engineering combines cell biology, chemistry, and biomaterials to create 3D tissues resembling the extracellular matrix, with a focus on nanofibrous structures.
- Electrospinning is a popular method for producing these nanofibers, as it allows for high porosity and surface area, while processing parameters significantly influence their structure.
- This review discusses recent advancements in electrospun nanofibers, covering surface modification techniques and their applications in regenerating various human tissues like bone, cartilage, vascular systems, and tendons.
Article Abstract
Tissue engineering uses a combination of cell biology, chemistry, and biomaterials to fabricate three dimensional (3D) tissues that mimic the architecture of extracellular matrix (ECM) comprising diverse interwoven nanofibrous structure. Among several methods for producing nanofibrous scaffolds, electrospinning has gained intense interest because it can make nanofibers with a porous structure and high specific surface area. The processing and solution parameters of electrospinning can considerably affect the assembly and structural morphology of the fabricated nanofibers. Electrospun nanofibers can be made from natural or synthetic polymers and blending them is a straightforward way to tune the functionality of the nanofibers. Furthermore, the electrospun nanofibers can be functionalized with various surface modification strategies. In this review, we highlight the latest achievements in fabricating electrospun nanofibers and describe various ways to modify the surface and structure of scaffolds to promote their functionality. We also summarize the application of advanced polymeric nanofibrous scaffolds in the regeneration of human bone, cartilage, vascular tissues, and tendons/ligaments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838281 | PMC |
| http://dx.doi.org/10.1186/s40580-019-0209-y | DOI Listing |
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