Report of 2 Novel Presentations of Subcutaneous Fat Necrosis of the Newborn.

Dermatopathology (Basel)

Department of Radiology, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, Massachusetts, USA.

Published: June 2019

Subcutaneous fat necrosis of the newborn (SCFNN) is a rare form of panniculitis classically affecting healthy full-term infants. There are a number of predisposing factors including perinatal asphyxia. The condition generally has a benign course with spontaneous resolution, but monitoring for metabolic complications, in particular the potentially life-threatening complication of hypercalcaemia, is critical. The authors report 2 cases of preterm infants with perinatal asphyxia with atypical presentations of SCFNN: the first with bony involvement resembling Langerhans cell histiocytosis and with follicular pseudocarcinomatous hyperplasia on histology; and the second presenting with a huge haematoma requiring surgical debridement. Both cases were initially erroneously diagnosed as pyogenic infections.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827445PMC
http://dx.doi.org/10.1159/000497176DOI Listing

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