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miR-619-5p and cardiogenic shock in patients with ST-segment elevation myocardial infarction.
Eur J Clin Invest
August 2024
Cardiovascular-Program ICCC, Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain.
Article Synopsis
- Cardiogenic shock (CS) is a life-threatening condition linked to severe heart issues, particularly in patients with ST-segment elevation myocardial infarction (STEMI), where the role of epigenetic factors, like miRNAs, is not well understood.
- In a study involving 49 STEMI patients, researchers found that miR-619-5p levels were significantly higher in those experiencing CS compared to those without, indicating its potential as a biomarker for assessing risk and mortality outcomes.
- The study concluded that miR-619-5p not only correlates with inflammatory responses but also serves as a critical indicator for predicting patient mortality within a 30-day follow-up in CS patients.
Circulating microRNAs predict recurrence and death following venous thromboembolism.
J Thromb Haemost
October 2023
Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Partner Site Rhine-Main, German Centre for Cardiovascular Research (DZHK), Mainz, Germany; Institute of Molecular Biology (IMB), Mainz, Germany. Electronic address:
Background: Recurrent events frequently occur after venous thromboembolism (VTE) and remain difficult to predict based on established genetic, clinical, and proteomic contributors. The role of circulating microRNAs (miRNAs) has yet to be explored in detail.
Objectives: To identify circulating miRNAs predictive of recurrent VTE or death, and to interpret their mechanistic involvement.
A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study.
Gastroenterology
September 2023
Italian Institute for Genomic Medicine, Turin, Italy; Candiolo Cancer Institute, FPO-IRCCS, Turin, Italy. Electronic address:
Background & Aims: Fecal tests currently used for colorectal cancer (CRC) screening show limited accuracy in detecting early tumors or precancerous lesions. In this respect, we comprehensively evaluated stool microRNA (miRNA) profiles as biomarkers for noninvasive CRC diagnosis.
Methods: A total of 1273 small RNA sequencing experiments were performed in multiple biospecimens.
Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.
Front Immunol
December 2021
Translational Type 1 Diabetes Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Type 1 diabetes is an immune-driven disease, where the insulin-producing beta cells from the pancreatic islets of Langerhans becomes target of immune-mediated destruction. Several studies have highlighted the implication of circulating and exosomal microRNAs (miRNAs) in type 1 diabetes, underlining its biomarker value and novel therapeutic potential. Recently, we discovered that exosome-enriched extracellular vesicles carry altered levels of both known and novel miRNAs in breast milk from lactating mothers with type 1 diabetes.
View Article and Find Full Text PDFSerum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus.
World J Gastroenterol
May 2020
Discipline of Surgery, College of Medicine and Public Health, Flinders University of South Australia, Adelaide, SA 5042, Australia.
Background: Circulating microRNAs (miRNAs) are potential biomarkers for many diseases. However, they can originate from non-disease specific sources, such as blood cells, and compromise the investigations for miRNA biomarkers. While small extracellular vesicles (sEVs) have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery, the most suitable blood sample for sEV miRNA biomarker studies has not been defined.
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