In the fight against vector-borne arboviruses, an important strategy of control of epidemic consists in controlling the population of the vector, mosquitoes in this case. Among possible actions, two techniques consist either in releasing sterile mosquitoes to reduce the size of the population (Sterile Insect Technique) or in replacing the wild population by one carrying a bacteria, called blocking the transmission of viruses from insects to humans. This article addresses the issue of optimizing the dissemination protocol for each of these strategies, in order to get as close as possible to these objectives. Starting from a mathematical model describing population dynamics, we study the control problem and introduce the cost function standing for and Then, we establish some properties of the optimal control and illustrate them with numerical simulations.
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http://dx.doi.org/10.3934/mbe.2019313 | DOI Listing |
Commun Biol
January 2025
Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Aedes mosquitoes transmit pathogenic arthropod-borne (arbo) viruses, putting nearly half the world's population at risk. Blocking virus replication in mosquitoes is a promising approach to prevent arbovirus transmission, the development of which requires in-depth knowledge of virus-host interactions and mosquito immunity. By integrating multi-omics data, we find that heat shock factor 1 (Hsf1) regulates eight small heat shock protein (sHsp) genes within one topologically associated domain in the genome of the Aedes aegypti mosquito.
View Article and Find Full Text PDFInsects
January 2025
West Valley Mosquito and Vector Control District, 1295 East Locust St, Ontario, CA 91761, USA.
is of great public health concern because of its vectorial capacity to transmit various arboviruses such as Zika, yellow fever, dengue, and chikungunya. In California, its expanding geographic distribution has been unrestrained. This urgently calls for innovative tools such as the use of sterile insect technique (SIT) to strengthen invasive control.
View Article and Find Full Text PDFInsects
December 2024
Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Morogoro P.O. Box 53, Tanzania.
Interspecific competition between mosquito larvae may affects adult vectorial capacity, potentially reducing disease transmission. It also influences population dynamics, and cannibalistic and predatory behaviors. However, knowledge of interspecific competition between and species is limited.
View Article and Find Full Text PDFInsects
December 2024
Laboratório de Biologia, Controlee Vigilância de InsetosVetores, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, RJ, Brazil.
Background: Yellow fever (YF) is an acute hemorrhagic disease endemic to Africa and Latin America; however, no cases have been reported in Asian regions with high infestation. Factors such as environmental conditions and genetic variations in the yellow fever virus (YFV) strains and mosquito populations may explain this absence. Mosquito populations have undergone strong selective pressure owing to the excessive use of insecticides.
View Article and Find Full Text PDFBiomedicines
December 2024
School of Health Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Unlabelled: Japanese Encephalitis (JE) is the leading cause of viral encephalitis in regions with endemic Japanese Encephalitis Virus (JEV) infections.
Background/objectives: The aim of this review is to consider the potential role of artificial intelligence (AI) to improve detection, monitoring and public health interventions for JE.
Discussion: As climate change continues to impact mosquito population growth patterns, more regions will be affected by mosquito-borne diseases, including JE.
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