A DNA Switch for Detecting Single Nucleotide Polymorphism within a Long DNA Sequence Under Denaturing Conditions.

Chemistry

M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.

Published: January 2020

Invited for the cover of this issue is the group of Yingfu Li at McMaster University. The image depicts a molecular switch for ultra-specific detection of DNA utilizing a guanine-quadruplex (up-right structure) resistant to denaturation by urea (ball-and-stick structures). Read the full text of the article at 10.1002/chem.201903536.

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201904777DOI Listing

Publication Analysis

Top Keywords

dna switch
4
switch detecting
4
detecting single
4
single nucleotide
4
nucleotide polymorphism
4
polymorphism long
4
long dna
4
dna sequence
4
sequence denaturing
4
denaturing conditions
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!