Plastic binding feature of polymyxins: the effect on MIC susceptibility measurements.

Infect Drug Resist

Infectious Disease Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Published: August 2019

The loss of polycationic antimicrobial peptides, polymyxins, due to adhesion to plastics is an important subject matter that influences in vitro susceptibility testing, including minimum inhibitory concentration (MIC) assays. This review reminds us that this issue can serve as a significant source of variation in the MIC values for polymyxins against Gram-negative bacteria.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717857PMC
http://dx.doi.org/10.2147/IDR.S219130DOI Listing

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