Increasing amount of fructose-1-phosphate aldolase activity in rat blood serum and induction of chromosomal aberrations in rat bone marrow cells were observed after injection of acrylamide. The cytotoxic activity of acrylamide in rat depended on the dose. Methylmethacrylate and butyl methacrylate demonstrated no such activity.
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Comput Biol Chem
January 2025
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea; Elicure, 12, Gyeongyeol-ro 17 beon-gil, Seo-gu, Gwangju, Republic of Korea. Electronic address:
This study aimed to profile metabolites from five Trichoderma strains and assess their cytotoxic and pharmacological activities, particularly targeting oral squamous cell carcinoma (OSCC). UHPLC-TOF-MS analysis revealed the presence of 25 compounds, including heptelidic acid, viridiol isomers, and sorbicillinol from the different Trichoderma extracts. Pharmacokinetic analysis showed moderate permeability and low interaction with P-glycoprotein, suggesting good drug absorption with minimal interference in cellular uptake.
View Article and Find Full Text PDFToxicon
January 2025
Faculty of Biological and Environmental Sciences, Federal University of Grande Dourados (UFGD), Dourados-Itahum Highway, Km 12 - Unit II, University City, 79804-970, Dourados, MS, Brazil; Faculty of Exact Sciences and Technology, Federal University of Grande Dourados (UFGD), Dourados-Itahum Highway, Km 12 - Unit II, University City, 79804-970, Dourados, MS, Brazil.
The venom of Ectatomma brunneum is considered promising for drugs development. Therefore, it is important to evaluate its toxic potential and genetic instability using biological assays. To this end, toxicity assays were performed with Artemia salina, cytotoxicity and genotoxicity with Allium cepa and mutagenicity with Ames.
View Article and Find Full Text PDFPlants (Basel)
January 2025
College of Agriculture and Environmental Science (CAES), University of South Africa, Priva Bag X06, Florida 0710, South Africa.
Plants have long been used to treat serious illnesses in both humans and animals. A significant underappreciated medicinal tree, Sond is utilized by many different ethnic groups to cure a wide range of illnesses. A variety of electronic databases, including ScienceDirect, Scopus, Scielo, Scifinder, PubMed, Web of Science, Medline, and Google Scholar, were used to search the literature on , using key words such as uses, survey, pharmacology, antigonococcal, toxicity, phytochemistry and others.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Siberian Branch of the Russian Academy of Sciences Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentieva Ave., 630090 Novosibirsk, Russia.
The apurinic/apyrimidinic site (AP site) is a highly mutagenic and cytotoxic DNA lesion. Normally, AP sites are removed from DNA by base excision repair (BER). Methoxyamine (MOX), a BER inhibitor currently under clinical trials as a tumor sensitizer, forms adducts with AP sites (AP-MOX) resistant to the key BER enzyme, AP endonuclease.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Department of Food Science & Technology, Seoul Women's University, Seoul 01797, Republic of Korea.
Titanium dioxide (TiO), a white color food additive, is widely used in bakery products, candies, chewing gums, soups, and creamers. Concerns about its potential genotoxicity have recently emerged, particularly following the European Union's ban on its usage as a food additive due to its genotoxicity potential. Conflicting in vitro and in vivo results regarding its genotoxicity highlight the need for further in-depth investigation.
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