AI Article Synopsis
- The study investigates the physicochemical properties of vascular grafts (VGs) made from a mixture of Tecoflex, gelatin, and bivalirudin using electrospinning, comparing them to traditional e-PTFE grafts.
- After 24 weeks of implantation in Wistar rats, 94.5% of the Tec-GL-BV grafts remained occlusion-free, significantly outperforming the 66.6% occlusion-free rate of e-PTFE grafts.
- Additionally, the Tec-GL-BV grafts showed more neovascularization and less neointima thickness and calcification, indicating their potential advantages in clinical applications.
Article Abstract
General physicochemical properties of the vascular grafts (VGs) produced from the solutions of Tecoflex (Tec) with gelatin (GL) and bivalirudin (BV) by electrospinning are studied. The electrospun VGs of Tec-GL-BV and expanded polytetrafluoroethylene (e-PTFE) implanted in the abdominal aorta of 36 Wistar rats have been observed over different time intervals up to 24 weeks. A comparison shows that 94.5% of the Tec-GL-BV VGs and only 66.6% of e-PTFE VGs (р = 0.0438) are free of occlusions after a 6 month implantation. At the intermediate observation points, Tec-GL-BV VGs demonstrate severe neovascularization of the VG neoadventitial layer as compared with e-PTFE grafts. A histological examination demonstrates a small thickness of the neointima layer and a low level of calcification in Tec-GL-BV VGs as compared with the control grafts. Thus, polyurethane-based protein-enriched VGs have certain advantages over e-PTFE VGs, suggesting their utility in clinical studies.
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| http://dx.doi.org/10.1088/1748-605X/ab550c | DOI Listing |
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Electrospun polyurethane-based vascular grafts: physicochemical properties and functioning in vivo.
Biomed Mater
December 2019
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, 630055 Russia.
Article Synopsis
- The study investigates the physicochemical properties of vascular grafts (VGs) made from a mixture of Tecoflex, gelatin, and bivalirudin using electrospinning, comparing them to traditional e-PTFE grafts.
- After 24 weeks of implantation in Wistar rats, 94.5% of the Tec-GL-BV grafts remained occlusion-free, significantly outperforming the 66.6% occlusion-free rate of e-PTFE grafts.
- Additionally, the Tec-GL-BV grafts showed more neovascularization and less neointima thickness and calcification, indicating their potential advantages in clinical applications.
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