AI Article Synopsis
- Browning induction or transplantation of brown adipose tissue (BAT) has potential as a treatment for metabolic diseases, but a lack of understanding of brown adipocyte differentiation hinders therapy development.
- The study focuses on how brown adipocytes develop from progenitor cells in mouse embryos, discovering that lipid droplet formation begins within glycogen clusters.
- Glycogen is degraded through a process called glycophagy, providing necessary substrates for creating lipid droplets and highlighting its important role in fat cell development.
Article Abstract
Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057258 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2019.09.073 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!