[This corrects the article DOI: 10.1371/journal.pbio.1002580.].
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| http://dx.doi.org/10.1371/journal.pbio.3000558 | DOI Listing |
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Intervertebral disc degenerative disease in South Africa: a case-control analysis of selected gene variants.
Mol Biol Rep
September 2024
Precision Medicine Unit, Department of Biotechnology, University of the Western Cape, Cape Town, South Africa.
Background: Intervertebral disc (IVD) degenerative disease is a multifactorial disease for which genetics plays an integral role. Several genes, and their variants, associated with the development and progression of IVD degenerative disease have been identified. While several studies have investigated these genes in Asian and European populations, no available evidence exists for the South African population.
View Article and Find Full Text PDFInvestigating the association between serum ADAM/ADAMTS levels and bone mineral density by mendelian randomization study.
BMC Genomics
July 2023
Department of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China.
Purpose: A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) have been reported potentially involved in bone metabolism and related to bone mineral density. This Mendelian Randomization (MR) analysis was performed to determine whether there are causal associations of serum ADAM/ADAMTS with BMD in rid of confounders.
Methods: The genome-wide summary statistics of four site-specific BMD measurements were obtained from studies in individuals of European ancestry, including forearm (n = 8,143), femoral neck (n = 32,735), lumbar spine (n = 28,498) and heel (n = 426,824).
Heritable Risk and Protective Genetic Components of Glaucoma Medication Non-Adherence.
Int J Mol Sci
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Neuroscience Graduate Program, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY 14203, USA.
Glaucoma is the leading cause of irreversible blindness, affecting 76 million globally. It is characterized by irreversible damage to the optic nerve. Pharmacotherapy manages intraocular pressure (IOP) and slows disease progression.
View Article and Find Full Text PDFCorrection: lncRNA PSMB8-AS1 promotes colorectal cancer progression through sponging miR-1299 to upregulate ADAMTS5.
Neoplasma
February 2023
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This corrects the article DOI: 10.4149/neo_2022_220111N42.
View Article and Find Full Text PDFCorrection: Inhibition of SMAD3 effectively reduces ADAMTS‑5 expression in the early stages of osteoarthritis.
BMC Musculoskelet Disord
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