AI Article Synopsis
- This paper discusses the challenges of analyzing metabolites in biofluids with nuclear magnetic resonance due to interference from water and macromolecules.
- It critiques the common pulse sequence used for signal suppression (presat-CPMG) and highlights its limitations.
- New pulse sequences are proposed and their effectiveness is shown through a metabolomic study of patients with multiple sclerosis (MS).
Article Abstract
Analysis of metabolites in biofluids using nuclear magnetic resonance often requires the suppression of obscuring signals arising from water and macromolecules. This paper analyses the limitations of the pulse sequence most commonly used to achieve such suppression (presat-CPMG) and proposes new pulse sequences that do not share those limitations. The utility of these improved pulse sequences is demonstrated in a metabolomic study of multiple sclerosis (MS) patients.
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| http://dx.doi.org/10.1039/c9an01005j | DOI Listing |
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