trachylobane-3-hydroperoxide, a new diterpene from the root bark of (Fam.; Euphorbiaceae).

New trachylobane-3-hydroperoxide together with four known compounds, ricinine , trimethoxy ellagic acid , dimethoxy ellagic acid and aleurotolic acid were isolated from the methylene chloride fraction of the root bark of . The structures of these secondary metabolites were elucidated by using different spectroscopic techniques, H NMR, C NMR, HSQC, HMBC, H-H COSY, NOESY, HR-ESI-MS, EI-MS and comparison with published data. trachylobane-3-hydroperoxide showed moderate cytotoxic activity by MTT assay method against human breast cancer cells (MCF-7) and human hepatocyte-derived carcinoma cells (Huh-7) with IC values of 24.53 and 34.13 µM, in comparison with IC values of 23.47 µM and 15.82 µM for 5-fluorouracil respectively.