The clinical approach to the critically ill patient has changed dramatically over the last several decades from one of deep sedation to that of mobilizing patients on mechanical ventilation and limiting sedation. The ABCDEF bundle is a multidisciplinary, evidence-based approach to the holistic management of critically ill patients that aims to optimize patient recovery, minimize iatrogenesis, and engage and empower the patient and family during their hospitalization. To achieve this goal, the bundle includes assessments for pain, delirium, and readiness to stop sedation and to start spontaneous breathing trials. It also encourages early mobilization of the patient, avoidance of restraints, and engagement with the family in bedside rounds to improve communication. Performance of this bundle reduces mortality, ventilator days, intensive care readmissions, delirium, coma, restraint use, and discharge to facilities in a dose-dependent manner. The respiratory therapist, as a key member of the critical care team, is essential to the implementation, performance, and success of the ABCDEF bundle. This review aims to describe each component of the ABCDEF bundle, provide evidence for both the impact of individual interventions as well as the entire bundle, and detail the importance of this multidisciplinary approach to the care of the critically ill patient.
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http://dx.doi.org/10.4187/respcare.07235 | DOI Listing |
SAGE Open Med
January 2025
Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
Objectives: This study investigated the implementation of the ABCDEF bundle and the factors associated with its implementation according to national income levels.
Methods: This study is cross-sectional research. We conducted a secondary analysis of an international 1-day point-prevalence study that investigated the implementation of the ABCDEF bundle in critically ill patients.
Crit Care Explor
December 2024
Division of Critical Care Medicine, Montefiore Medical Center, Bronx, NY.
Importance: "Awake" cannulation for venovenous extracorporeal membrane oxygenation (ECMO), where patients remain spontaneously breathing without invasive mechanical ventilation during the cannulation procedure, may reduce lung injury from positive pressure ventilation and promote patient mobility.
Objectives: To examine the association between "awake" cannulation for venovenous ECMO and patient outcomes.
Design, Setting, And Participants: Analysis of the prospectively collected by the multicenter Extracorporeal Life Support Organization registry.
Crit Care Clin
January 2025
Vanderbilt University School of Nursing, 461 21st Avenue South, 419 Godchaux Hall, Nashville, TN 37240, USA; Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center at Vanderbilt, Nashville, TN, USA. Electronic address:
The ABCDEF bundle and Awake and Walking intensive care unit (ICU) approach aim to prevent the long-term consequences of critical illness (ie, post-intensive care syndrome) by promoting patient wakefulness, cognition, and mobility. Humanizing the ICU experience is the key, preserving patients' function and autonomy. Successful implementation requires cultivating an ICU culture focused on avoiding sedatives and initiating prompt mobilization, addressing organizational barriers through tailored strategies.
View Article and Find Full Text PDFNurs Crit Care
October 2024
Department of Pulmonary Diseases, Division of Intensive Care Medicine, School of Medicine, Karadeniz Technical University, Trabzon, Türkiye.
Background: Early mobilization are key components of the ABCDEF Care Bundle and critical treatments to reduce acquired muscle weakness, delirium and prolonged intensive care unit (ICU) stay.
Aim: This study aimed to determine whether routine early mobilization related to intracranial pressure in intensive care patients on mechanical ventilation, using optic nerve sheath diameter measurement (ONSD).
Study Design: This study was planned as a prospective, cohort study in the third-step adult ICU of a faculty hospital.
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