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Conversion of Lignocellulosic Biomass Into Valuable Feed for Ruminants Using White Rot Fungi.
J Anim Physiol Anim Nutr (Berl)
January 2025
Department of Animal Science, Wageningen University & Research, Wageningen, The Netherlands.
White rot fungi can degrade lignin and improve the nutritional value of highly lignified biomass for ruminants. We screened for excellent fungi-biomass combinations by investigating the improvement of digestibility of wheat straw, barley straw, oat straw, rapeseed straw, miscanthus, new reed, spent reed from thatched roofs, and cocoa shells after colonisation by Ceriporiopsis subvermispora (CS), Lentinula edodes (LE), and Pleurotus eryngii (PE) (indicated by increased in vitro gas production [IVGP]). First, growth was evaluated for three fungi on all types of biomass, over a period of 17 days in race tubes.
View Article and Find Full Text PDFDifferential Inhibition by Cenobamate of Canonical Human Nav1.5 Ion Channels and Several Point Mutants.
Int J Mol Sci
January 2025
Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
Cenobamate is a new and highly effective antiseizure compound used for the treatment of adults with focal onset seizures and particularly for epilepsy resistant to other antiepileptic drugs. It acts on multiple targets, as it is a positive allosteric activator of γ-aminobutyric acid type A (GABA) receptors and an inhibitor of neuronal sodium channels, particularly of the late or persistent Na current. We recently evidenced the inhibitory effects of cenobamate on the peak and late current component of the human cardiac isoform hNav1.
View Article and Find Full Text PDFα-Acid Glycoprotein with Highly Fucosylated Glycans as a Potential Diagnostic Marker for Early Detection of Hepatobiliary and Pancreatic Cancers.
Diagnostics (Basel)
December 2024
Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
: Previously, we reported elevated levels of fucosylated α-acid glycoprotein (fAGP) in plasma samples from patients with diverse types of cancers. Accordingly, fAGP was assumed to be a potential biomarker for the early detection of cancers. : The fAGP level was retrospectively measured in preoperative plasma samples from 213 patients with either hepatic, biliary tract, or pancreatic cancer and was analyzed together with levels of six existing tumor markers determined as reference standards.
View Article and Find Full Text PDFPolyethylene Glycol (PEG) Application Triggers Plant Dehydration but Does Not Accurately Simulate Drought.
Plants (Basel)
December 2024
College of Science and Engineering, Biological Sciences, Flinders University, Adelaide, SA 5042, Australia.
Polyethylene glycol (PEG), especially at high molecular weights, is highly soluble in water, and these solutions have reduced water potential. It is convenient to use PEG in hydroponics (liquid nutrient solution) for experiments with plants. However, some authors have been found to describe the application of PEG to plants incorrectly, such as drought, dehydration, osmotic, or water stresses, which can mislead readers.
View Article and Find Full Text PDFTending to the Facial Surfaces of a Mathematical Biology Head-Scratcher: Why Does the Head of the Sea Turtle Resemble a Convex Zygomorphic Dodecahedron?
Animals (Basel)
January 2025
Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA.
Two convex polyhedra that markedly resemble the head of the flatback sea turtle hatchling are identified. The first example is a zygomorphic tetragonal dodecahedron, while the other, an even better matching structure, is a related tetradecahedron, herein speculated to arise from this particular dodecahedron via known mechanisms gleaned from studies of the behavior of foams. A segmented, biomorphic, convex polyhedral model to address cephalic topology is thus presented stemming from solid geometry, anatomical observations, and a recently computed densest local packing arrangement of fifteen slightly oblate spheroids in which fourteen oblate spheroids surround a central such spheroid.
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