[Not Available].

Objective:: To examine associations of hair cortisol concentration (HCC) in mid-childhood and change in HCC from mid-childhood to early adolescence (ΔHCC) with early adolescent adiposity and cardiometabolic biomarker measures.

Methods:: In Project Viva, a pre-birth cohort of mothers and children, we measured HCC in 599 white children in mid-childhood and in 426 of these participants in early adolescence. We used multivariable linear regression to examine associations of mid-childhood HCC and ΔHCC with BMI-for-age-and-sex z-score, waist circumference, waist-height ratio, dual X-ray absorptiometry total and trunk fat mass, a metabolic risk z-score, adiponectin, HOMA-IR, high-density lipoprotein, C-reactive protein, interleukin-6, leptin, and systolic blood pressure.

Results:: Over a mean (SD) follow-up of 5.2 (0.8) years, we did not find associations of mid-childhood HCC with BMI-for-age-and-sex z-score (β=0.00 per 1-interquartile range of HCC, 95% confidence interval [CI]: −0.08, 0.07), waist circumference (β=−0.04cm, 95% CI: −0.83, 0.74), metabolic risk z-score (β=0.04, 95% CI: −0.03, 0.11), or other cardiometabolic measures except for an increase in log-transformed HOMA-IR (β=0.10, 95% CI: 0.04, 0.17). ΔHCC was not associated with any outcome measures.

Conclusions:: We found that mid-childhood HCC was not associated with early adolescent adiposity or cardiometabolic biomarkers except for a slight increase in HOMA-IR.