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| http://dx.doi.org/10.1016/j.eucr.2018.10.011 | DOI Listing |
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Evaluating H2BC9 as a potential diagnostic and prognostic biomarker in head and neck squamous cell carcinoma.
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Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Background: Histone H2B is highly expressed in many types of cancers and is involved in cancer development. H2B clustered histone 9 (H2BC9), a member of the H2B family, plays critical roles in gene expression regulation, chromosome structure, DNA repair stability, and cell cycle regulation. However, the diagnostic and prognostic value of H2BC9 in head and neck squamous cell carcinoma (HNSCC) remains unclear.
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School of Cyber Science and Engineering, Sichuan University, Chengdu, China.
The presence of a positive deep surgical margin in tongue squamous cell carcinoma (TSCC) significantly elevates the risk of local recurrence. Therefore, a prompt and precise intraoperative assessment of margin status is imperative to ensure thorough tumor resection. In this study, we integrate Raman imaging technology with an artificial intelligence (AI) generative model, proposing an innovative approach for intraoperative margin status diagnosis.
View Article and Find Full Text PDFAn improved sparrow search algorithm with multi-strategy integration.
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Addressing the shortcomings of the Sparrow Search Algorithm (SSA), such as low accuracy of convergence and tendency of falling into local optimum, a Multi-strategy Integrated Sparrow Search Algorithm (MISSA) is proposed. In this method, by improving the black-winged kite algorithm and applying it to the producer's position update formula, an improved search strategy (ISS) is firstly proposed to enhance search ability. Secondly, a new strategy inspired by the Coot algorithm, called the group follow strategy (GFS), is proposed to improve the ability to jump out of the local optimum.
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Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Integration of human papillomavirus (HPV) into the host genome drives HPV-positive head and neck squamous cell carcinoma (HPV HNSCC). Whole-genome sequencing of 51 tumors revealed intratumor heterogeneity of HPV integration, with 44% of breakpoints subclonal, and a biased distribution of integration breakpoints across the HPV genome. Four HPV physical states were identified, with at least 49% of tumors progressing without integration.
View Article and Find Full Text PDFImpacts of irrigation expansion on moist-heat stress based on IRRMIP results.
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Department of Water and Climate, Vrije Universiteit Brussel, Brussels, Belgium.
Irrigation rapidly expanded during the 20 century, affecting climate via water, energy, and biogeochemical changes. Previous assessments of these effects predominantly relied on a single Earth System Model, and therefore suffered from structural model uncertainties. Here we quantify the impacts of historical irrigation expansion on climate by analysing simulation results from six Earth system models participating in the Irrigation Model Intercomparison Project (IRRMIP).
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