Cholesterol homeostasis is critical and necessary for the body's functions. Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular disease (CVD). 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and low-density lipoprotein cholesterol receptor (LDLR) are major points of control in cholesterol homeostasis. We summarize the regulatory mechanisms of HMGCR and LDLR, which may provide insight for new drug design and development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709517 | PMC |
| http://dx.doi.org/10.2147/DMSO.S219013 | DOI Listing |
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