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The role of blood purification therapies in the treatment of chronic kidney disease-associated pruritus: a systematic review.
Clin Kidney J
September 2024
Department of Nephrology, Dialysis and Trasplantation, San Bortolo Hospital, Vicenza, Italy.
Chronic kidney disease-associated pruritus (CKD-aP) is a common complication in dialysis patients which is not fully addressed by pharmacological and dialytic therapy. The objective was to review the literature on the effects of extracorporeal blood purification modalities on CKD-aP. The population comprised patients aged ≥18 years on chronic dialysis.
View Article and Find Full Text PDFEmerging therapeutic strategies targeting extracellular histones for critical and inflammatory diseases: an updated narrative review.
Front Immunol
August 2024
Department of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China.
Article Synopsis
- Extracellular histones play a key role in various severe inflammatory diseases, like sepsis and acute liver failure, by triggering hyperinflammation and organ dysfunction.
- Recent studies have shown that therapies aimed at neutralizing histones or using blood purification can reduce their harmful effects and improve outcomes in animal models.
- The review highlights current knowledge of histone-related mechanisms and therapeutic strategies, while also addressing the need for thorough evaluations of these treatments for effective use in clinical settings.
Blood Purification in Hepatic Dysfunction after Liver Transplant or Extensive Hepatectomy: Far from the Best-Case Scenarios.
J Clin Med
May 2024
Department of Gastroenterological, Endocrine, Metabolic and Nephro-Urological Sciences, General Surgery and Hepatobiliary Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
: Hepatic dysfunction (HD) after liver transplantation (LT) or extended hepatic resection (EHR) is associated with graft failure and high short-term mortality. We evaluated the safety and depurative efficacy of CytoSorb® in these settings. The primary endpoint was the change in serum total bilirubin at the end of the treatment compared to the baseline value.
View Article and Find Full Text PDFCytokine adsorption in patients with acute-on-chronic liver failure (CYTOHEP): A single center, open-label, three-arm, randomized, controlled intervention pilot trial.
Artif Organs
October 2024
Interdisciplinary Medical Intensive Care, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Background: To investigate the efficacy of bilirubin reduction by hemoadsorption with CytoSorb® in patients with acute-on-chronic liver failure (ACLF) receiving continuous renal replacement therapy (CRRT).
Methods: A prospective, randomized, single-center, open-label, controlled pilot trial. Patients with ACLF, acute kidney injury, and serum bilirubin ≥5 mg/dL were assigned 1:1:1 to one of three study groups (CRRT with or without hemoadsorption, no CRRT).
Relationship Between Symmetrical Peripheral Gangrene Patients and Using Vasopressors in the Intensive Care Unit.
Cureus
April 2024
College of Medicine, King Faisal University, Al-Hofuf, SAU.
Symmetrical peripheral gangrene (SPG) is a rare yet severe condition characterized by peripheral ischemic lesions without significant vascular occlusion. Its clinical presentation includes peripheral cyanosis, mottling, and symmetrical ischemia of distal limbs, often progressing to gangrene. Recent years have seen a rise in SPG cases, with mortality rates ranging from 40% to 90%.
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