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Tailoring osteoimmunity and hemostasis using 3D-Printed nano-photocatalytic bactericidal scaffold for augmented bone regeneration.
Biomaterials
May 2025
Department of Biosystems Engineering, Kangwon National University, Chuncheon, 24341, Republic of Korea; Institute of Forest Science, Kangwon National University, Chuncheon, 24341, Republic of Korea; Interdisciplinary Program in Smart Agriculture, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address:
Bone hemorrhage, infection, and large bone defects following surgical treatment of traumatic bone injury have raised potential concerns, underscoring the urgent need to develop multifunctional therapeutic platforms that can effectively address traumatic bone regeneration. Advancements in three-dimensional (3D) printing technology have propelled the development of several engineering disciplines, such as tissue engineering. Nevertheless, 3D-printed frameworks with conventional materials often lack multifunctional capabilities to promote specific activities for diverse regeneration purposes.
View Article and Find Full Text PDFBone tissue engineering necessitates the development of scaffolds with optimal properties to provide a suitable microenvironment for cell adhesion, proliferation, and osteogenic differentiation. The selection of appropriate scaffold materials remains a critical challenge in this field. In this study, we aimed to address this challenge by evaluating and comparing the performance of hydrogel scaffolds reinforced with -tricalcium phosphate (-TCP), allograft, and a combination of allograft and strontium hydroxyapatite (SrHA).
View Article and Find Full Text PDFThermosensitive alginate-gelatin-nitrogen-doped carbon dots scaffolds as potential injectable hydrogels for cartilage tissue engineering applications.
RSC Adv
May 2021
Institute of Nano Science and Nano Technology, University of Kashan P. O. Box. 87317-51167 Kashan I. R. Iran +98 31 55913201 +98 31 5591 2383.
Hybrid injectable and biodegradable hydrogels based on oxidized alginate/gelatin and containing nitrogen-doped carbon dots (NCDs) as a reinforcement have been fabricated and crosslinked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/-hydroxysuccinimide (NHS) as the chemical crosslinking agents in the hydrogel system. The idea of composite hydrogels relies on the assumption that they supply a microenvironment that is convenient for the exchange of nutrients a porous structure and cell proliferation and have mechanical characteristics that approximately match natural tissue. The effect of the NCD content on the morphology structure, mechanical strength, swelling ratio, and biodegradation has been investigated.
View Article and Find Full Text PDFstudy of alginate-gelatin scaffolds incorporated with silica NPs as injectable, biodegradable hydrogels.
RSC Adv
April 2021
Department of Cell and Developmental Biology, School of Biological Sciences, College of Science, University of Tehran Tehran Iran.
Porous substrates composed of biodegradable polymers and nanoparticles have found extensive use as three-dimensional (3D) scaffolds to regenerate damaged tissues through the incorporation of cells or growth factors. Here, injectable thermally responsive hydrogels based on SiO nanoparticles (NPs), alginate, and gelatin biopolymers, with possible utilization for cartilage tissue engineering, are introduced. The nanocomposites contain different amounts of SiO NPs for reinforcement and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)/-hydroxysuccinimide (NHS) for chemical crosslinking of polymer chains in the 3D hydrogel network.
View Article and Find Full Text PDFNanohybrid-Reinforced Gelatin-Ureidopyrimidinone-Based Self-healing Injectable Hydrogels for Tissue Engineering Applications.
ACS Appl Bio Mater
June 2021
Tissue Engineering and Biomaterials Laboratory, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India.
The traditional hydrogels are prone to break due to the applied stress. The deformation of the implanted hydrogels would result in the loss of structural integrity, leading to the failure of hydrogel functionalities and tissue regeneration. Self-healing hydrogels (AG-UPy), composed of oxidized alginate and ureidopyrimidinone-functionalized gelatin (G-UPy), were developed to address this challenge.
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