Microwave photonic bandpass filters (MPBPFs) are important building blocks in radio-frequency (RF) signal processing systems. However, most of the reported MPBPFs fail to satisfy the stringent real-world performance metrics, particularly low RF insertion loss. In this paper we report a novel MPBPF scheme using two cascaded integrated silicon nitride (SiN) ring resonators, achieving a high link gain in the RF filter passband. In this scheme, one ring operates at an optimal over-coupling condition to enable a strong RF passband whilst an auxiliary ring is used to increase the detected RF signal power via tuning the optical carrier-to-sideband ratio. The unique combination of these two techniques enables compact size as well as high RF performance. Compared to previously reported ring-based MPBPFs, this work achieves a record-high RF gain of 1.8 dB in the passband, with a high spectral resolution of 260 MHz. Furthermore, a multi-band MPBPF with optimized RF gain, tunable central frequencies, and frequency spacing tunability is realized using additional ring resonators, highlighting the scalability and flexibility of this chip-based MPBPF scheme.
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http://dx.doi.org/10.1364/OE.27.031727 | DOI Listing |
Soc Sci Med
January 2025
Department of Media and Communication, City University of Hong Kong, 18 Tat Hong Avenue, Kowloon Tong, Hong Kong. Electronic address:
This study examines the effects of gain-loss framing, messaging modality, peer influence, and individual factors such as social norms and self-efficacy on the attitudes and intentions to reduce sedentary behaviors among university students, specifically through (a) taking breaks and (b) taking 10,000 steps daily. We conducted a two-week health campaign field experiment on Instagram in January 2022, delivering ten posts with tailored messages to 284 university students in Singapore (valid N = 249). The participants were predominantly female (70.
View Article and Find Full Text PDFLearn Health Syst
January 2025
Department of Biomedical Informatics University of Arkansas for Medical Sciences, College of Medicine Little Rock Arkansas USA.
Objective: This project demonstrates the feasibility of connecting medical imaging data and features, SARS-CoV-2 genome variants, with clinical data in the National Clinical Cohort Collaborative (N3C) repository to accelerate integrative research on detection, diagnosis, and treatment of COVID-19-related morbidities. The N3C curated a rich collection of aggregated and de-identified electronic health records (EHR) data of over 18 million patients, including 7.5 million COVID-positive patients, seen at hospitals across the United States.
View Article and Find Full Text PDFJ Obes Metab Syndr
January 2025
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
Obesity is a major global health concern, with diet playing a crucial role in its development and treatment. Ultra-processed foods (UPFs) have become prevalent in diets due to changes in the food environment. These foods are energy-dense; high in fat, sugars, or salt; and low in fiber, protein, vitamins, and minerals, raising concerns about their effects on health.
View Article and Find Full Text PDFNat Chem Biol
January 2025
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Voltage-gated ion channels (VGICs) are crucial targets for neuropsychiatric therapeutics owing to their role in controlling neuronal excitability and the established link between their dysfunction and neurological diseases, highlighting the importance of identifying modulators with distinct mechanisms. Here we report two small-molecule modulators with the same chemical scaffold, Ebio2 and Ebio3, targeting a potassium channel KCNQ2, with opposite effects: Ebio2 acts as a potent activator, whereas Ebio3 serves as a potent and selective inhibitor. Guided by cryogenic electron microscopy, patch-clamp recordings and molecular dynamics simulations, we reveal that Ebio3 attaches to the outside of the inner gate, employing a unique non-blocking inhibitory mechanism that directly squeezes the S6 pore helix to inactivate the KCNQ2 channel.
View Article and Find Full Text PDFTissue Cell
January 2025
Department of Endocrinology, Fuyang Cancer Hospital, Fuyang, Anhui Province 236000, PR China. Electronic address:
Background: Diabetes mellitus (DM), a chronic metabolic disease, is characterized by long-term hyperglycemia resulting from the defect of insulin production and insulin resistance. The damage and dysfunction of pancreatic β-cells is a main link in DM development.
Methods: In this work, pancreatic β-cell line INS-1E cells were exposed to 30 mM glucose for 48 h to construct an in vitro DM model.
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