The nanoindentation method was applied to determine the elastic modulus and hardness of knee articular cartilage. Cartilage samples from both high weight bearing (HWB) and low weight bearing (LWB) femoral condyles were collected from patients diagnosed with osteoarthritis (OA). The mean elastic modulus of HWB cartilage was 4.46 ± 4.44 MPa in comparison to that of the LWB region (9.81 ± 8.88 MPa, < 0.001). Similarly, the hardness was significantly lower in HWB tissue (0.317 ± 0.397 MPa) than in LWB cartilage (0.455 ± 0.434 MPa, < 0.001). When adjusted to patients' ages, the mean elastic modulus and hardness were both significantly lower in the age group over 70 years ( < 0.001). A statistically significant difference in mechanical parameters was also found in grade 3 and 4 OA. This study provides an insight into the nanomechanical properties of the knee articular cartilage and provides a starting point for personalized cartilage grafts that are compatible with the mechanical properties of the native tissue.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912408 | PMC |
| http://dx.doi.org/10.3390/jcm8111865 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Formulation Design of Orally Disintegrating Film Using Two Cellulose Derivatives as a Blend Polymer.
Pharmaceutics
January 2025
Laboratory of Advanced Pharmaceutical Process Engineering, Gifu Pharmaceutical University, 5-6-1 Mitahora-Higashi, Gifu 502-8585, Japan.
: Orally disintegrating film (ODF) is prepared using water-soluble polymers as film-forming agents. To improve mechanical and disintegration properties, some polymers need to be blended with others. This study aimed to investigate the utility of hydroxypropyl cellulose (HPC) and hydroxypropyl methyl cellulose (HPMC) as blend film-forming components for ODFs.
View Article and Find Full Text PDFExploring the Effect of Annealing on PLA/Carbon Nanotube Nanocomposites: In Search of Efficient PLA/MWCNT Nanocomposites for Electromagnetic Shielding.
Polymers (Basel)
January 2025
Academic Unit of Materials Engineering, Federal University of Campina Grande, Av. Aprígio Veloso, 882-Bodocongó, Campina Grande 58429-900, PB, Brazil.
In this research, poly(lactic acid) (PLA) nanocomposites with multi-walled carbon nanotubes (MWCNT) were produced by extrusion, injection, and compression molding, focusing on electromagnetic shielding. Various amounts of carbon nanotubes (MWCNTs) were tested in PLA matrix, specifically ranging from 1 to 4 parts per hundred resin (phr). The resulting nanocomposites were analyzed before and after undergoing annealing heat treatment.
View Article and Find Full Text PDFEnhancing the Mechanical and Adhesive Properties of Polyurethane Adhesives with Propylene Oxide-Modified Ethylenediamine (PPO-EDA).
Polymers (Basel)
January 2025
Green Chemistry & Materials Group, Korea Institute of Industrial Technology (KITECH), Cheonan 31056, Republic of Korea.
This study explores the use of propylene oxide-modified ethylenediamine (PPO-EDA) as a novel crosslinker and chain extender in polyurethane (PU) adhesives. PPO-EDA was synthesized and compared with ,-dimethylethylenediamine (DMEDA) to assess its impact on mechanical properties and adhesion performance. Key parameters such as NCO conversion, tensile strength, and lap shear strength were thoroughly evaluated.
View Article and Find Full Text PDFImproved Biomineralization Using Cellulose Acetate/Magnetic Nanoparticles Composite Membranes.
Polymers (Basel)
January 2025
Department of Dental Medicine and Nursing, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Following implantation, infections, inflammatory reactions, corrosion, mismatches in the elastic modulus, stress shielding and excessive wear are the most frequent reasons for orthopedic implant failure. Natural polymer-based coatings showed especially good results in achieving better cell attachment, growth and tissue-implant integration, and it was found that the inclusions of nanosized fillers in the coating structure improves biomineralization and consequently implant osseointegration, as the nanoparticles represent calcium phosphate nucleation centers and lead to the deposition of highly organized hydroxyapatite crystallites on the implant surface. In this study, magnetic nanoparticles synthesized by the co-precipitation method were used for the preparation of cellulose acetate composite coatings through the phase-inversion method.
View Article and Find Full Text PDFEffect of Crystallinity on the Printability of Poly(ethylene Terephthalate)/Poly(butylene Terephthalate) Blends.
Polymers (Basel)
January 2025
Institute of Polymers, Composites and Biomaterials, National Research Council, via Previati n.1/E, 23900 Lecco, Italy.
This study explores the impact of blending polyethylene terephthalate (PET) with polybutylene terephthalate (PBT) on the thermal, structural, and mechanical properties of 3D-printed materials. Comprehensive analyses, including Fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and mechanical testing, were conducted to assess the influence of blend composition. FT-IR confirmed that PET and PBT blend physically without transesterification, while TGA showed enhanced thermal stability with increasing PET content.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!