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Growth Inhibitory Activity of Leaf Extracts Against . | LitMetric
Acne vulgaris is a common skin disease affecting adolescents and young adults of all ethnic groups, negatively impacting self-esteem, self-confidence, and social life. The Gram-positive bacteria colonizes the sebum-rich follicle and contributes to inflammation of the pilosebaceous gland. Long-term antibiotic therapies targeting lead to the development of antimicrobial resistance, and novel acne vulgaris therapies are needed. This study investigated the inhibitory activity of leaves, a native Southeastern United States shrub historically used by Native Americans to treat fever, stomachache, and pruritis. Flash chromatography fractions of the ethyl acetate-soluble ethanol leaf extract (649C-F9 and 649C-F13) exhibited MICs ranging from 16 to 32 µg ml and IC range of 4-32 μg ml against a panel of 10 distinct isolates. Cytotoxicity against an immortalized human keratinocyte cell line (HaCaTs) skin was detected at more than eight times the dose required for growth inhibitory activity (IC of 256 μg ml for 649C-F9 and IC of >512 μg ml for 649C-F13). This work highlights the potential of leaf extracts as a cosmeceutical ingredient for the management of acne vulgaris. Further research is necessary to assess its mechanism of action and efficacy.
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