AI Article Synopsis
- Psychoactive drugs during pregnancy can harm brain development in offspring, potentially causing neurological disorders; caffeine is the most commonly consumed drug in this context.
- A study found that offspring of THY-Tau22 transgenic mice exposed to caffeine showed earlier cognitive decline compared to those treated with water.
- Caffeine exposure altered how neurons in the hippocampus responded to Tau pathology, suggesting it may increase the risk of early onset Alzheimer's-like symptoms in offspring.
Article Abstract
Psychoactive drugs used during pregnancy can affect the development of the brain of offspring, directly triggering neurological disorders or increasing the risk for their occurrence. Caffeine is the most widely consumed psychoactive drug, including during pregnancy. In Wild type mice, early life exposure to caffeine renders offspring more susceptible to seizures. Here, we tested the long-term consequences of early life exposure to caffeine in THY-Tau22 transgenic mice, a model of Alzheimer's disease-like Tau pathology. Caffeine exposed mutant offspring developed cognitive earlier than water treated mutants. Electrophysiological recordings of hippocampal CA1 pyramidal cells revealed that early life exposure to caffeine changed the way the glutamatergic and GABAergic drives were modified by the Tau pathology. We conclude that early-life exposure to caffeine affects the Tau phenotype and we suggest that caffeine exposure during pregnancy may constitute a risk-factor for early onset of Alzheimer's disease-like pathology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797851 | PMC |
| http://dx.doi.org/10.3389/fncel.2019.00438 | DOI Listing |
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