AI Article Synopsis
- The 3D organization of the genome plays a crucial role in regulating gene expression and is linked to the development of diseases, especially cancers.
- This article reviews the changes in 3D genome structure related to cancer and discusses the phenomenon of cancer cells relying heavily on specific gene expressions (transcriptional addiction).
- The authors also explore how certain drugs can disrupt 3D genome organization and raise important considerations related to the discovery of a new drug that significantly affects genome structure.
Article Abstract
The role of 3D genome organization in the precise regulation of gene expression is well established. Accordingly, the mechanistic connections between 3D genome alterations and disease development are becoming increasingly apparent. This opinion article provides a snapshot of our current understanding of the 3D genome alterations associated with cancers. We discuss potential connections of the 3D genome and cancer transcriptional addiction phenomenon as well as molecular mechanisms of action of 3D genome-disrupting drugs. Finally, we highlight issues and perspectives raised by the discovery of the first pharmaceutical strongly affecting 3D genome organization.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929230 | PMC |
| http://dx.doi.org/10.1016/j.molmed.2019.09.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!