AI Article Synopsis
- The study focuses on how highly charged lipid bilayers behave when monovalent counterions are present, revealing that the water layer between similar charged bilayers is thinner compared to zwitterionic lipids.
- Experimental findings indicate an unexpected attractive interaction between these charged bilayers, which contradicts classical theories of electrostatics.
- The results highlight the limitations of traditional electrostatic models in tightly confined spaces and demonstrate how surface charges can alter the orientation of water molecules, reducing the effective dielectric constant.
Article Abstract
We investigate the interaction between highly charged lipid bilayers in the presence of monovalent counterions. Neutron and X-ray reflectivity experiments show that the water layer between like-charged bilayers is thinner than for zwitterionic lipids, demonstrating the existence of counterintuitive electrostatic attractive interaction between them. Such attraction can be explained by taking into account the correlations between counterions within the Strong Coupling limit, which falls beyond the classical Poisson-Boltzmann theory of electrostatics. Our results show the limit of the Strong Coupling continuous theory in a highly confined geometry and are in agreement with a decrease in the water dielectric constant due to a surface charge-induced orientation of water molecules.
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| http://dx.doi.org/10.1021/acs.jpclett.9b02804 | DOI Listing |
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