AI Article Synopsis
- Insect growth regulators (IGRs) are being explored as safer alternatives to traditional insecticides, with actinomycetes potentially offering new compounds for this purpose.
- The study screened 363 actinomycetes and identified Streptomyces sp. AN120537 as the most effective, which produced juvenile hormone antagonists (JHANs) and showed strong insecticidal effects.
- Five active compounds known as antimycins were isolated, demonstrating significant insecticidal activities and causing deformities in treated larvae, indicating their potential application as broad-spectrum IGR insecticides.
Article Abstract
Insect growth regulators (IGRs) are attractive alternatives to chemical insecticides. Since it has been reported that secondary metabolites from actinomycetes show insecticidal activities against various insect pests, actinomycetes could be a potential source of novel IGR compounds. In the present study, insect juvenile hormone antagonists (JHANs) were identified from actinomycetes and their insect growth regulatory and insecticidal activities were investigated. A total of 363 actinomycetes were screened for their insect growth regulatory and insecticidal activities against Aedes albopictus and Plutella xylostella. Among them, Streptomyces sp. AN120537 showed the highest JHAN and insecticidal activities. Five antimycins were isolated as active compounds by assay-guided fractionation and showed high JHAN activities. These antimycins also exhibited significant insecticidal activities against A. albopictus, P. xylostella, F. occidentalis, and T. urticae. Moreover, dead larvae treated with these antimycins displayed morphological deformities that are similar to those of JH-based IGR-treated insects. This is the first report demonstrating that the insecticidal activities of antimycins resulted from their possible JHAN activity. Based on our results, it is expected that novel JHAN compounds potentially derived from actinomycetes could be efficiently applied as IGR insecticides with a broad insecticidal spectrum.
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| http://dx.doi.org/10.1016/j.cbpc.2019.108651 | DOI Listing |
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