AI Article Synopsis
- A study examined the relationship between specific gene polymorphisms (rs4025935, rs1695, rs71748309, rs1800566) in GSTM1, GSTT1, and NQO1 genes and the risk of developing classical Ph-negative myeloproliferative neoplasms in a Caucasian population from the Vyatka region of Russia.
- The findings revealed that the NQO1*609T allele, certain NQO1*609T genotypes, and a homozygous deletion (null) allele of the GSTT1 gene are significantly associated with an increased risk of these neoplasms, with various odds ratios indicating potential risk factors.
- Conversely, no
Article Abstract
The correlation of gene polymorphisms rs4025935 (large deletion), rs1695 (313A>G), rs71748309 (large deletion), and rs1800566 (609C>T) of GSTM1, GSTT1, and NQO1 genes encoding glutathione-S-transferases (GST) M1, P1, and T1 and NADPH-quinone oxidoreductase with the risk of development of classical Ph-negative myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, and primary myelofibrosis) was studied in the Caucasian ethnicity population of Vyatka region of the Russian Federation. It was found that NQO1*609T allele, NQO1*609T genotypes, and homozygous carriage of a deletion (null) allele of GSTT1 gene are associated with the risk of development of myeloproliferative neoplasms (OR=1.29, 95%CI=1.02-1.64, p=0.04; OR=1.39, 95%CI=1.04-1.85, p=0.03; and OR=1.48, 95%CI=1.03-2.12, p=0.03, respectively). However, no influence of GSTM1 and GSTP1 gene polymorphisms on the risk of development of myeloproliferative disorders was registered.
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| http://dx.doi.org/10.1007/s10517-019-04619-5 | DOI Listing |
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