Pathogenic memory plasma cells in autoimmunity.

Curr Opin Immunol

Deutsches Rheuma-Forschungszentrum Berlin, a Leibniz Institute (DRFZ), Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

Published: December 2019

• Memory plasma cells are long-lived but require specialized niches for their survival. • Memory plasma cells are refractory to conventional immunosuppression. • Pathogenic memory plasma cells represent ‘roadblocks’ to response to conventional therapy. • Strategies for (selective) targeting of memory plasma cells are in preclinical and clinical tests.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908965PMC
http://dx.doi.org/10.1016/j.coi.2019.09.005DOI Listing

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