Self-healing hydrogels were prepared from hydrazide functionalized poly(aspartic acid) (PAsp). The polymer succinimide (PSI) was reacted with hydrazine and ethanolamine successively to obtain water soluble poly(aspartic acid) derivatives with hydrazide functional groups (PAEH). The hydrogel was prepared by cross-linking PAEH with poly(ethylene glycol) dialdehyde (PEG DA) under mild conditions without addition of catalyst. The rheological property and the self-healing property of the hydrogels were investigated intensively. The in vitro toxicity experiment showed the hydrogels have good bio-compatibility and the doxorubicin (DOX)-loaded hydrogels showed controlled release profile. Importantly, the hydrogel can still be degraded based on poly(aspartic acid) backbone. The bio-degradable poly(amino acid) based on self-healing hydrogel could have great potential application in bioscience including tissue repairing, drug loading and release.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.colsurfb.2019.110601 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tailored multilayer nanoparticles against resistant P. aeruginosa by disrupting the thickened mucus, dense biofilm and hyperinflammation.
J Control Release
December 2024
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China. Electronic address:
Therapeutic challenges of chronic pulmonary infections caused by multidrug-resistant Pseudomonas aeruginosa (MDRP. aeruginosa) biofilms due to significantly enhanced antibiotic resistance. This resistance is driven by reduced outer membrane permeability, biofilm barriers, and excessive secretion of virulence factors.
View Article and Find Full Text PDFFunctional remineralization of dentin artificial caries lesions via poly-L-aspartic acid‑calcium complexes.
Int J Biol Macromol
January 2025
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China. Electronic address:
Article Synopsis
- Dental caries is a prevalent oral issue that currently lacks effective treatment, prompting a study to assess the remineralization potential of two processes: polyelectrolyte‑calcium complexes pre-precursor (PCCP) and polymer-induced liquid-like precursors (PILP) on artificial caries lesions in dentin.
- The study utilized various advanced imaging and analytical techniques, showing that the PCCP process significantly enhanced mineral content and mechanical properties of dentin lesions compared to the PILP process, which had limited effectiveness.
- Ultimately, the results suggest that PCCP could be a promising method for successfully restoring dentin caries lesions, offering a potential new strategy for dental care.
Antioxidant hydrogel from poly(aspartic acid) and carboxymethylcellulose with quercetin loading as burn wound dressing.
Int J Biol Macromol
December 2024
College of Chemistry and Materials Science, Hebei University, Baoding City, Hebei Province 071002, China; Key Laboratory of Pathogenesis mechanism and control of inflammatory-autoimmune diseases in Hebei Province, Hebei University, Baoding City, Hebei Province 071002, China. Electronic address:
Susceptibility to infection and excessive accumulation of reactive oxygen species (ROS) are the greatest obstacles for burn wound healing. In this research, the 5-aminosalicylic acid (ASA) grafted poly(aspartic hydrazide) (PASH) was synthesized by successive ploysuccinimide (PSI) ring opening reaction and reacted with oxidized carboxymethyl cellulose (DCMC) to fabricate biodegradable hydrogel through Schiff-base cross-linking. Moreover, the hydrogel was loaded with quercetin (QT) to enhance its anti-inflammatory performance.
View Article and Find Full Text PDFConstructing the Enamel-Like Dentin Adhesion Interface to Achieve Durable Resin-Dentin Adhesion.
ACS Nano
October 2024
Department of Stomatology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, 218 Jixi Road, Hefei 230032, China.
Enamel adhesion is acknowledged as durable; however, achieving long-lasting dentin adhesion remains a formidable challenge due to degradation of exposed collagen matrix after acid-etching of dentin. The idea of developing an enamel-like adhesion interface holds great promise in achieving enduring dentin adhesion. In this study, we constructed an enamel-like adhesion interface using a rapid remineralization strategy comprising an acidic primer and a rapid remineralization medium.
View Article and Find Full Text PDFInfluence of Protective Colloids on Calcium Tartrate Stability and the Astringency Perception in a Red Wine.
Foods
September 2024
Instituto de Ciencias Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, Av. El Llano Subercaseaux 2801, San Miguel, Santiago 8910060, Chile.
Calcium tartrate instability in wines has been a neglected topic for many years. However, it seems that this problem is gaining prominence, and the industry welcomes inputs to address this issue. Among the alternatives that winemakers use for tartrate salt stabilization, the addition of authorized protective colloids is one of the best choices because they are easy to apply and have a low energetic cost.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!