The possibility of one-step creating of pH-sensitive mesostructured silica-based nanocontainers with exceptionally high payload using associates of two antiseptics (including hydrolyzable one) as templates is demonstrated. The effects of the template nature and the conditions of the sol-gel process on the porous structure of silica nanocontainers are studied and discussed. The kinetics of the templating drug release from such containers is studied and some features of this process are analyzed. It is shown that the drug release rate can be tuned by varying the medium pH. The bactericidal activity of two encapsulated antiseptics against the Staphylococcus aureus is evaluated in vitro by agar diffusion method with replacement of agar with agarose. The diameters of the inhibition zones for silica-based containers loaded with antiseptics increased with the pre-diffusion time at 4 °C. At the same time, empty containers (after elimination of antiseptics by etching) did not reveal any bactericidal properties.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.colsurfb.2019.110577 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nanolabels Prepared by the Entrapment or Self-Assembly of Signaling Molecules for Colorimetric and Fluorescent Immunoassays.
Biosensors (Basel)
December 2024
Henan Province Key Laboratory of New Opto-Electronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China.
Nanomaterials have attracted significant attention as signal reporters for immunoassays. They can directly generate detectable signals or release a large number of signaling elements for readout. Among various nanolabels, nanomaterials composed of multiple signaling molecules have shown great potential in immunoassays.
View Article and Find Full Text PDFSilica nanocontainers with rhodamine B acylhydrazone for early fluorescent detection of steel corrosion.
RSC Adv
December 2024
Research Institute for Physical Chemical Problems, Belarusian State University Leningradskaya Str. 14 220006 Minsk Belarus
Article Synopsis
- Developing efficient fluorescent sensors for metal corrosion is important, but sensitive sensors can lose effectiveness when exposed to different coatings.
- Silica nanocontainers are used to encapsulate rhodamine B acylhydrazone, which acts as a pH sensor, and these nanomaterials are applied in low concentrations in water-based epoxy and acrylic coatings to detect early corrosion in steel.
- The encapsulated dye shows 4 times greater fluorescence response to corrosion compared to non-encapsulated, while also enhancing dye dispersion and coating barrier properties without needing solvents.
Signal amplification strategy based on target-controlled release of mediator for ultrasensitive self-powered biosensing of acetamiprid.
Talanta
January 2025
Institute for Chemical Biology & Biosensing, College of Life Sciences, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China. Electronic address:
Self-powered biosensors with high sensitivity have garnered significant interest for their potential applications in the realm of portable sensing. Herein, a self-powered biosensor with a novel signal amplification strategy was developed by integrating target-controlled release of mediator with an enzyme biofuel cell for the ultrasensitive detection of acetamiprid (ACE). Zeolitic imidazolate framework-67 was utilized as both a nanocontainer for capturing the electron mediator 2,2'-azidobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and a precursor for the synthesis of cobalt nanoparticles/nitrogen, sulfur-codoped carbon nanotubes (Co NPs/NS-CNTs), which were employed as the electrode material for constructing both the glucose oxidase-based bioanode and the laccase-based biocathode.
View Article and Find Full Text PDFStabilized, ROS-sensitive β-cyclodextrin-grafted hyaluronic supramolecular nanocontainers for CD44-targeted anticancer drug delivery.
Colloids Surf B Biointerfaces
October 2024
Postdoctoral Mobile Station of Basic Medical Sciences, Hengyang Medical School, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study& School of Pharmaceutical Science, University of South China, Hengyang 421001, China. Electronic address:
Hyaluronic acid (HA)-based tumor microenvironment-responsive nanocontainers are attractive candidates for anticancer drug delivery due to HA's excellent biocompatibility, biodegradability, and CD44-targeting properties. Nevertheless, the consecutive synthesis of stabilized, stealthy, responsive HA-based multicomponent nanomedicines generally requires multi-step preparation and purification procedures, leading to batch-to-batch variation and scale-up difficulties. To develop a facile yet robust strategy for promoted translations, a silica monomer containing a cross-linkable diethoxysilyl unit was prepared to enable in situ crosslinking without any additives.
View Article and Find Full Text PDFNIR-responsive magnesium phosphate cement loaded with simvastatin-nanoparticles with biocompatibility and osteogenesis ability.
RSC Adv
April 2024
School of Materials Science and Engineering, Southeast University Nanjing 211189 China
The insufficient osteogenesis of magnesium phosphate cement (MPC) limits its biomedical application. It is of great significance to develop a bioactive MPC with osteogenic performance. In this study, an injectable MPC was reinforced by the incorporation of a near infrared (NIR)-responsive nanocontainer, which was based on simvastatin (SIM)-loaded mesoporous silica nanoparticles (MSNs) modified with a polydopamine (PDA) bilayer, named SMP.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!