Radiation of leaky modes existing in anisotropic waveguides can be cancelled by destructive interference at special propagation directions relative to the optical axis orientation, resulting in fully bound states surrounded by radiative modes. Here we study the variation of the loci of such special directions in terms of the waveguide constitutive parameters. We show that the angular loci of the bound states are sensitive to several design parameters, allowing bound states to exist for a broad range of angular directions and wavelengths and suggesting applications in filtering and sensing.
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http://dx.doi.org/10.1364/OL.44.005362 | DOI Listing |
Nucleic Acids Res
January 2025
Department of Physics, 845 W Taylor St, University of Illinois Chicago, Chicago, IL 60607, USA.
Altered DNA dynamics at lesion sites are implicated in how DNA repair proteins sense damage within genomic DNA. Using laser temperature-jump (T-jump) spectroscopy combined with cytosine-analog Förster Resonance Energy Transfer (FRET) probes that sense local DNA conformations, we measured the intrinsic dynamics of DNA containing 3 base-pair mismatches recognized in vitro by Rad4 (yeast ortholog of XPC). Rad4/XPC recognizes diverse lesions from environmental mutagens and initiates nucleotide excision repair.
View Article and Find Full Text PDFBiophys J
January 2025
Department of Physics, Northeastern University, Boston, MA, 02115, USA. Electronic address:
Binuclear ruthenium complexes have been investigated for potential DNA-targeted therapeutic and diagnostic applications. Studies of DNA threading intercalation, in which DNA base pairs must be broken for intercalation, have revealed means of optimizing a model binuclear ruthenium complex to obtain reversible DNA-ligand assemblies with the desired properties of high affinity and slow kinetics. Here, we used single-molecule force spectroscopy to study a binuclear ruthenium complex with a longer semi-rigid linker relative to the model complex.
View Article and Find Full Text PDFSensors (Basel)
January 2025
School of Mechanical and Electrical Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China.
Unsupervised Domain Adaptation for Object Detection (UDA-OD) aims to adapt a model trained on a labeled source domain to an unlabeled target domain, addressing challenges posed by domain shifts. However, existing methods often face significant challenges, particularly in detecting small objects and over-relying on classification confidence for pseudo-label selection, which often leads to inaccurate bounding box localization. To address these issues, we propose a novel UDA-OD framework that leverages scale consistency (SC) and Temporal Ensemble Pseudo-Label Selection (TEPLS) to enhance cross-domain robustness and detection performance.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Institute of Robotics, Autonomous System and Sensing, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, UK.
Knee joint disorders pose a significant and growing challenge to global healthcare systems. Recent advancements in robotics, sensing technologies, and artificial intelligence have driven the development of robot-assisted therapies, reducing the physical burden on therapists and improving rehabilitation outcomes. This study presents a novel knee exoskeleton designed for safe and adaptive rehabilitation, specifically targeting bed-bound stroke patients to enable early intervention.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 20201, USA.
Brain ischemia causes disruption in cerebral blood flow and blood-brain barrier integrity, which are normally maintained by astrocyte endfeet. Emerging evidence points to dysregulation of the astrocyte translatome during ischemia, but its effects on the endfoot translatome are unknown. In this study, we aimed to investigate the early effects of ischemia on the astrocyte endfoot translatome in a rodent cerebral ischemia and reperfusion model of stroke.
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