Geographic location continues to be an important indicator in incidence of, access to treatment for, and mortality from breast cancer. Disparities in access to screening and early detection persist in Appalachian Virginia. We developed an index to identify sites which would most benefit from increased frequency of mobile mammography visits, based on geographically relevant population-level risk factors (late stage of tumor diagnosis) and accessibility risk factors (access to FDA [US Food and Drug Administration] mammography sites, access of women aged 50+ years to primary care physicians at existing mobile sites). These 4 components for the Priority Index were subsequently standardized and multiplied to importance weights. The percentage of mammograms performed in the target geographic region has increased each year, respectively. This article presents methodological considerations for developing a priority algorithm to increase access to breast cancer early screening and detection for vulnerable women.
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http://dx.doi.org/10.1177/1073274819883270 | DOI Listing |
Sci Rep
January 2025
Bioinformatics Centre, Savitribai Phule Pune University, Pune, Maharashtra, 411007, India.
COVID-19 has proved to be a global health crisis during the pandemic, and the emerging JN.1 variant is a potential threat. Therefore, finding alternative antivirals is of utmost priority.
View Article and Find Full Text PDFActa Neuropathol Commun
January 2025
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College (PUMC) and Chinese Academy of Medical Science (CAMS), Beijing, China.
Mutations in the ANXA11 gene, encoding an RNA-binding protein, have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but the underlying in vivo mechanisms remain unclear. This study examines the clinical features of ALS patients harboring the ANXA11 hotspot mutation p.P36R, characterized by late-onset motor neuron disease and occasional multi-system involvement.
View Article and Find Full Text PDFBMJ Open
January 2025
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of).
Objectives: Microbial threats pose a growing concern worldwide. This paper reports the analysis of Iran's policy process against microbial threats.
Design: This is a qualitative study.
Mar Pollut Bull
January 2025
Molecular Invertebrate Systematics and Ecology Laboratory, Faculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan; Tropical Biosphere Research Center, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan. Electronic address:
The coastline of Okinawa Island, Japan, has been affected by human-made alterations for decades, often from land reclamation and coastal defense construction. Here, we use an Imperial Japanese Army map made between 1919 and 1921 to describe the composition of the Okinawan coastline approximately 100 years ago, and by overlapping this old map with a modern-day map of Okinawa (2018), we identified 131 sites where coastlines showed clear human-made alterations. For these sites, we examined what kinds of ecosystems were lost and what has replaced them.
View Article and Find Full Text PDFDisabil Rehabil Assist Technol
January 2025
School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada.
This exploratory qualitative study examines the challenges faced by manual wheelchair (MWC) users and their clinicians, with a focus on mobility difficulties in both outdoor and indoor environments, as well as training priorities. The study involved semi-structured interviews with 18 clinicians and 25 MWC users from various rehabilitation centres. The interviews, lasting between 30 and 60 minutes, explored specific aspects of MWC use, including mobility challenges, training needs, and psychological factors.
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